Zhejiang Provincial People's Hospital

Enzymatic cross-linking collagen-based bioink for 3D bioprinting of endometrial model with endometrial epithelial organoids

The human endometrium, a dynamic tissue responsive to sex hormones, plays a pivotal role in female reproduction and menstrual cycling, comprising diverse cell populations including epithelial and stromal cells. The development of in vitro endometrial models holds substantial pote...

Multi-omics profiling uncovers diagnostic biomarker panel, progression-associated subtypes, and prognostic signature in pediatric mitochondrial disease

Pediatric mitochondrial disease (PMD) is challenging due to its genetic heterogeneity, diagnostic difficulty, and unpredictable trajectories. Current biomarkers lack sensitivity to diagnose PMD or predict its severe course. Here, we show a multi-omics framework with longitudinal...

Dual-targeted nanotechnology for gynaecological cancers: a comprehensive review of mechanisms and clinical potential

Background Ovarian, cervical and endometrial cancers have been the leading cause of morbidity and mortality in women, often resulting from late diagnosis, resistance to therapies and off-target toxicity of conventional therapies.Discussion The review discusses recent progress in...

Autism spectrum disorder burden in China and worldwide, 1990–2021

Autism spectrum disorder (ASD) imposes a substantial public health burden. This study quantified and compared the ASD burden in China and globally from 1990 to 2021 to inform policy and planning. We analyzed Global Burden of Disease 2021 estimates of age-standardized prevalence r...

Temperature- and pH-Responsive Pickering Emulsions Stabilized by Chitosan−Metal Nanogels for Esterification Catalysis

Abstract In recent years, Pickering emulsions have been successfully applied in interfacial reaction systems due to their unique interfacial stability. The effective separation of products and the efficient recovery of catalysts and emulsions are key considerations in the design...

Ultrasound-mediated mechanical force perturbing plasma membrane properties for paclitaxel-resistant epithelial ovarian cancer therapy

Abstract Paclitaxel (PTX) resistance in epithelial ovarian cancer (EOC) is a significant clinical challenge, often resulting in cross-resistance to other chemotherapeutic agents and contributing to a low five-year survival rate. In recent years, the physical characteristics of tu...

Angelica keiskei extract inhibits LPS-induced activation of microglia and ameliorates acute cerebral ischemic injury in mice

Angelica keiskei (Miq.) Koidz. [Apiaceae] is a botanical drug with dual-purpose as food and medicine and its improvement in acute cerebral ischemic injury has not been studied. In the present study, we investigated the anti-neuroinflammatory and protective effects of the ethyl ac...

52‐week ivarmacitinib in moderate‐to‐severe atopic dermatitis: A phase 3 trial

BACKGROUND: Ivarmacitinib, an oral JAK1 inhibitor, improved efficacy outcomes versus placebo at Week 16 in a phase 3 trial in patients with moderate-to-severe atopic dermatitis (AD). OBJECTIVES: To describe efficacy and safety outcomes through Week 52. METHODS: In this multicentr...

High immunosuppressants variability adversely affects post-transplant recurrence for patients with hepatocellular carcinoma

Tumor recurrence after liver transplantation (LT) for hepatocellular carcinoma (HCC) is the most significant obstacle impacting the prognosis of patients. Managing the clinical application of immunosuppressive agents is difficult, owing to their limited therapeutic range and nota...

UGGT1 mediates N-glycosylation of LGALS3BP to induce angiogenesis in liver cancer via the NOTCH signaling pathway

Abstract Background Liver cancer (LC) is one of the leading causes of cancer-related deaths worldwide. Its complex vascular regulatory network and drug resistance severely limit clinical efficacy. Although LGALS3BP is highly expressed in various malignant tumors, its biological f...

Super-resolution CT-based intratumoral and peritumoral radiomics analysis for trinary classification of PD-L1 status in lung adenocarcinoma ≥ 1 cm

<title>Abstract</title> Objectives To explore the potential of super-resolution CT-based intratumoral and peritumoral radiomics analysis for the trinary classification of PD-L1 status in lung adenocarcinoma with a diameter of ≥ 1cm, aiming to enhance the accuracy of PD-L1 status...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Coexistence of high-risk HPV infection and FANCC heterozygous variation in early young esophageal squamous cell carcinoma: a case report and literature review

<title>Abstract</title> <bold>Background:</bold> Esophageal cancer poses a major health challenge in China, with current screening targeting individuals over 40. However, rising incidence in younger populations, often with atypical symptoms, leads to delayed diagnosis. Investigat...