Zhejiang Hospital

Healthy lifestyle as a protective factor against the risk of gastroesophageal reflux disease: Prospective population cohort analysis

Background Lifestyle modifications are recommended by American Gastroenterological Association (AGA) for managing gastroesophageal reflux disease (GERD), a significant health issue; but evidence is scarce. This study aims to investigate the longitudinal association between health...

New periodontal phenotype classification in patients with different types of malocclusion and dental crowding

Abstract Background The periodontal phenotype plays a critical role in periodontal stability and orthodontic risk assessment. However, an integrated evaluation of soft‐ and hard‐tissue periodontal characteristics across various sagittal and vertical skeletal patterns and dental c...

Quality, safety, and readability of consumer-facing generative AI responses to end-of-life questions relevant to surrogate decision-makers for older adults: a benchmark evaluation

As the population ages and the prevalence of multiple coexisting conditions increases, end-of-life decision-making for older adults is becoming increasingly complex in clinical practice. limited access to relevant medical information and differences in medical knowledge between c...

Tissue Olink Proteomics Analysis Reveals CCL17 as a Potential Biomarker in Patients With Pressure Ulcers

ABSTRACT Pressure ulcer (PU) typically arises as a chronic cutaneous ulcer stemming from a complex interplay of factors. However, the underlying mechanisms of this condition remain unclear. The aim of this study was to identify inflammatory biomarkers in patients with PU. In this...

Evaluating sex as a modifier of cardiomyocyte relaxation in heart failure with preserved ejection fraction: calcium handling, titin, and bioenergetics

Abstract Background Women are disproportionately affected by heart failure with preserved ejection fraction (HFpEF), particularly at older ages, but this epidemiological pattern does not establish sex-modified cardiomyocyte mechanisms. We evaluated whether current evidence suppor...

Impact of dynamic blood glucose trajectories on mortality in critically ill non-traumatic intracranial hemorrhage patients: a retrospective cohort study

Dysglycemia is frequently observed in patients with non-traumatic intracranial hemorrhage (ICH) and has been linked to adverse clinical outcomes. However, the prognostic impact of longitudinal blood glucose trajectories in critically ill non-traumatic intracranial hemorrhage rema...

eGFR partially mediates the association between Dietary Inflammatory Index and all-cause mortality in older adults

This study examines the association between the Dietary Inflammatory Index (DII) and all-cause mortality in older adults and investigates the mediating role of estimated glomerular filtration rate (eGFR) using National Health and Nutrition Examination Survey data. We included 630...

Small incision arthroscopically assisted disc anchorage of the anterior disc displacement of temporomandibular joint: part I - technique introduction

We describe a novel hybrid surgical technique, termed “small incision arthroscopically assisted disc anchorage” (SIAADA), for the treatment of anterior disc displacement (ADD) of the temporomandibular joint (TMJ). The aim of this study was to integrate the microinvasive benefits...

CAP-UNet: frequency-decoupled and geometry-aware attention for medical image segmentation across multiple imaging modalities

Accurate medical image segmentation is frequently hampered by pervasive challenges such as severe visual camouflage, extreme scale variations, and highly irregular anatomical boundaries across diverse imaging modalities. To address these challenges, we propose CAP-UNet, a geometr...

Elevated electrical stimulation thresholds for sciatic nerve block in individuals with diabetic complications: a systematic review and meta-analysis

Diabetes mellitus is associated with peripheral nerve structural alterations, potentially affecting nerve excitability. Electrical stimulation threshold is a key parameter for nerve localization during sciatic nerve block. This meta-analysis investigates the impact of diabetes me...

Two‐ to six‐year outcomes of tunnel technique with connective tissue graft in multiple mandibular anterior recessions

Abstract Background The purpose of this study is to report the 2–6 year outcomes of the tunnel technique with a connective tissue graft (TUN+CTG) in treating multiple Cairo recession type 1 and 2 recessions over a 2–6 year follow‐up, and the influence of CTG exposure on treatment...

The intratumoral microbiome as an emerging hub in cancer pathogenesis and precision oncology

Over the past decade, the number of microbial communities identified within tumors has increased by 400%. Notably, the intratumoral microbiome, which includes bacteria, fungi, viruses, and other microorganisms within tumor tissues, was first discovered more than a century ago. Ba...

Predictive Value of the Systemic Immune-Inflammation Index Combined With the Prognostic Nutritional Index for Flap-Related Complications Following Flap Repair in Patients With Stage Ⅲ and Ⅳ Pressure Injuries

AIM: To investigate the combined predictive value of systemic immune-inflammation index (SII) and prognostic nutritional index (PNI) for postoperative flap-related complications in patients with stage Ⅲ and Ⅳ pressure injuries undergoing flap repair.METHODS: A single-center retro...

Chemotherapy remains effective in ALK-TKI therapy: a retrospective analysis in ALK-positive advanced NSCLC

Tyrosine kinase inhibitors (TKIs) are the standard therapy for advanced non-small cell lung cancer (NSCLC) harboring anaplastic lymphoma kinase (ALK) fusions. However, acquired resistance remains a major challenge, necessitating strategies to prolong therapeutic efficacy. This st...

Integrating nutrition counseling into clinical skills training: a simulation-based interprofessional education program for medical and nursing students

The increasing prevalence of diet-related chronic diseases highlights the urgent need for effective nutrition education in health professions training. This study evaluated a simulation-based interprofessional education (IPE) program designed to enhance nutrition counseling knowl...

Successful surgical retrieval of an intracranial sewing needle retained for more than 45 years since infancy with complete fibrous encapsulation: a case report and literature review

Intracranial sewing needles are an extremely rare neurosurgical condition. Such injuries mostly occur during infancy, with the sewing needle penetrating intracranially through unclosed fontanelles. The clinical manifestations of intracranially retained sewing needles are often in...

Platelet count combined with Child-Turcotte-Pugh score for predicting rebleeding in cirrhotic patients with esophagogastric variceal bleeding

To investigate the predictive value of platelet count (PLT) combined with the Child-Turcotte-Pugh (CTP) score for rebleeding in cirrhotic patients with esophagogastric variceal bleeding (EGVB). This single-center retrospective study included 332 eligible patients selected from 37...

Associations of key diet-quality indexes with trajectory of multimorbidity: a prospective study in the UK Biobank

Dietary patterns have been associated with the morbidity and mortality of individual non-communicable diseases(NCDs). However, the impacts of baseline dietary patterns among the initially healthy population on the progression from healthy to first non-communicable disease (FNCD),...