Zhejiang Hisun Pharmaceutical (China)

Continuous-Flow Synthesis of the Key Nicergoline Intermediate 10α-Methoxy-9,10-dihydrolyserol via Photomethoxylation

Abstract At present, the key nicergoline intermediate 10α-methoxy-9,10-dihydrolyserol (3) is predominantly synthesized by photomethoxylation in batch photoreactors, a conventional method plagued by issues such as poor light penetration, low energy efficiency, severe scale-up barr...