Zhejiang Center for Disease Control and Prevention

Impact of the evolution of national ART guidelines and Initiation criteria on low–level viremia trends and predictors in Anhui Province: a sequential period analysis

Over the past two decades, China’s National Free Antiretroviral Treatment Program has undergone significant paradigm shifts. However, how evolving national ART guidelines and initiation criteria have shaped the long-term incidence of persistent low-level viremia (LLV) remains poo...

A Label‐Free Bioluminescent scFv‐NLuc Fusion Probe Enabling a Smartphone‐Based Sensitive Immunoassay Platform Using Lomefloxacin as a Model Analyte

ABSTRACT Enzymes as labeling agents enhance lateral flow immunoassays (LFIA). However, their biological instability and reliance on labor‐intensive chemical conjugation hinder practical high‐throughput screening of food contaminants. To address this, we report a rapid, label‐free...

Insulin resistance as a potential mediator between central obesity and diabetic kidney disease risk in type 2 diabetes

Abstract Obesity is a key risk factor for diabetic kidney disease (DKD). However, BMI fails to capture body fat distribution. We hypothesized that central obesity, rather than generalized obesity, is associated with DKD risk in patients with type 2 diabetes mellitus (T2DM), and t...

ACE2-PNA conjugates exploit viral endocytosis for targeted intracellular delivery and exhibit dual antiviral efficacy against SARS-CoV-2

The COVID-19 pandemic and its protracted consequences underscore the urgent need for more effective antiviral strategies. Current antiviral strategies face a persistent challenge achieving sufficient viral suppression while minimizing off-target toxicity, particularly against suc...