Zhangzhou Municipal Hospital of Fujian Province

Combined femoral nerve block and posterior knee pain-point infiltration for early passive knee training after total knee arthroplasty: a two-center sham-controlled proof-of-concept randomized trial

Abstract Background We assessed whether a combined regional analgesic regimen administered immediately before passive knee training on postoperative day 3 was associated with active knee range of motion (ROM) 90 days after the intervention. Methods In this two-center, parallel-gr...

Balloon guide catheter outcomes by occlusion site in the randomized PROTECT-MT trial

Background Balloon guide catheters (BGCs) are used during endovascular thrombectomy, but whether their effect varies by occlusion site is uncertain. We evaluated effect modification by baseline occlusion site in the PROTECT-MT trial. Methods This exploratory secondary analysis of...

Multiomics profiling identifies molecular and cellular signatures of regular exercise in human peripheral blood

Regular exercise is well established to protect against metabolic disorders and bolster immunity, but the underlying molecular and cellular mechanisms remain incompletely understood. We integrated plasma metabolomics and lipidomics with single-cell transcriptomic and chromatin ac...

Coordinated endocrine, metabolomic, feeding, behavioral, and gut microbiome changes and exploratory within-individual associations during musk secretion in forest musk deer (Moschus berezovskii)

Male forest musk deer undergo a seasonal musk secretion period accompanied by pronounced physiological and behavioral changes. However, whether endocrine and metabolic remodeling, feeding-related changes, and gut microbiome variation occur together within individuals during this...

Subdivision of metachronous metastatic nasopharyngeal carcinoma based on the framework of TNM-9: A recursive partitioning analysis of real-world data

Abstract Purpose: To validate the prognostic value of the M1 category in version nine of the AJCC/UICC TNM staging system (TNM-9) in metachronous metastatic nasopharyngeal carcinoma (mmNPC) and to develop a refined M1 classification for improved risk stratification. Methods: Pati...

Acridine-Based[68Ga]Ga- and [18F]AlF-Labeled PSMA RadiotracersEnabling High-Contrast PET Imagingwith Minimized Undesired Retention

Abstract Prostate-specific membrane antigen (PSMA)-targeted radioligands have achieved clinical success in prostate cancer imaging, yet nonspecific uptake in normal tissues remains a challenge. Here, we developed a series of acridine-based PSMA ligands and systematically investig...