Zhangjiagang First People's Hospital

U-shaped association of platelet-to-lymphocyte ratio with all-cause and cardiovascular mortality in hypertension: mediating role of renal dysfunction in a nationwide cohort (NHANES 2005–2018)

To evaluate the association between the platelet-to-lymphocyte ratio (PLR) and all-cause and cardiovascular mortality among adults with hypertension in the National Health and Nutrition Examination Survey (NHANES). We conducted a prospective cohort analysis using NHANES 2005–2018...

Development of a novel anoikis-related prognostic signature and validation of CD36 as a potential target for reversing 5-FU resistance in gastric cancer

Gastric cancer (GC) remains a leading cause of cancer-related mortality, with chemoresistance and metastasis being primary hurdles to effective treatment. Anoikis resistance is a critical survival mechanism enabling tumor dissemination; however, the cellular heterogeneity of anoi...

Effectiveness and Safety of Fixed‐Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real‐World Study From China

BACKGROUND: This study assessed the real-world effectiveness and safety of a fixed-dose combination (FDC) of metformin and empagliflozin in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective, multicenter, real-world study enrolled consecutive patient...

Upregulation of AK7 in ACC-VTA glutamatergic projections contributes to chronic inflammation pain in male mice

Abstract Chronic inflammation pain is a complex pathological condition involving multiple mechanisms in both the peripheral and central nervous systems. Growing evidence indicates that an imbalance in central nervous system function plays a crucial role in the progression of chro...

Chronic kidney disease due to hypertension in China, Japan, and the Republic of Korea: trends from the Global Burden of Disease Study 1990–2023

Abstract Objective To evaluate the burden and temporal trends of chronic kidney disease (CKD) attributable to hypertension in China, Japan, and the Republic of Korea from 1990 to 2023 using Global Burden of Disease (GBD) 2023 data. Methods Age-standardized incidence, mortality, a...

Nintedanib in the prevention of radiation-induced lung injury in patients with unresectable stage II-III NSCLC: A protocol for a randomized, multicenter, control group study

Background Radiation-induced lung injury (RILI) is a common and dose-limiting complication in patients with non-small cell lung cancer (NSCLC) receiving radiotherapy, especially in combination with chemotherapy and/or immunotherapy. RILI encompasses acute radiation pneumonitis (R...

Macrophage senescence and senescence-like states in senile osteoporosis: cellular cross-talk and therapeutic perspectives

Senile osteoporosis (SOP) is an age-related metabolic bone disease characterized by reduced bone quality and increased fracture risk, closely associated with immune senescence. Among immune components in the bone marrow niche, macrophages undergo age-associated phenotypic and fun...