Zanjan University of Medical Sciences

Spontaneous pneumomediastinum secondary to profound weight loss and malnutrition: a case report and review of malnutrition as a primary etiology

Spontaneous pneumomediastinum (SPM) is a rare but significant complication of anorexia nervosa (AN). While historically linked to Valsalva maneuvers, a growing body of evidence implicates severe malnutrition as an associated risk factor, challenging traditional etiologic models....

Plasma p-tau217 as a two-cutoff approach to improve tau-PET screening and trial recruitment in Alzheimer’s disease

Abstract Blood-based biomarkers could broaden access to Alzheimer’s disease diagnostics, but their ability to approximate tau PET, and to address gray-zone results, remains uncertain. We evaluated plasma p-tau217 against tau PET using a harmonized ADNI baseline cohort and an inde...