Yunnan Institute of Endemic Diseases Control and Prevention

Virome Diversity and Host-Associated Heterogeneity in Mosquitoes and Biting Midges Across Yunnan, China

Mosquitoes and biting midges harbor diverse viruses, but the factors shaping their viromes remain incompletely understood. We analyzed 35 pooled libraries from seven host groups across 15 locations in Yunnan, China, sampled in June 2025, using total-RNA sequencing, viral annotati...

Genetic and pharmacological evidence linking CB1R signaling to hippocampal GABAergic dysfunction in ASD mouse model

Autism spectrum disorder (ASD) is a neurodevelopmental disorder increasingly linked to disrupted GABAergic inhibition and altered excitatory-inhibitory balance. Cannabinoid receptor 1 (CB1R), enriched on GABAergic interneurons, modulates inhibitory tone. Whether CB1R dysfunction...

Prevalence of Keshan disease at the township level in China: a cross-sectional study

Keshan disease (KD), an endemic myocardiopathy with unclear etiology, lacks primary preventive measures. This study aimed to assess the prevalence of KD at the township level using spatial epidemiology, elucidate its distribution characteristics for further precision classificati...

Long-Term Evidence of ENSO-Driven Rodent Population Dynamics in a Natural Plague Focus of Southwestern China

Climate variability can modulate zoonotic disease risk by altering interactions among wildlife hosts, vectors, and human environments, yet long-term evidence linking large-scale climate oscillations to natural plague systems remains scarce. We investigated the influence of El Niñ...