Yonsei University Health System

A practical guide to automated test assembly for educational evaluation in health professions: a demonstration using the R package ROI

Automated test assembly (ATA) using mixed-integer programming (MIP) is standard practice in international testing organizations, but detailed and accessible practical guidelines remain scarce for health professions assessment. This study introduces the mathematical foundations of...

Ultrafast Magneto‐Geometric Control of Terahertz Helicity in Curved Ni Metasurfaces

ABSTRACT Dynamic helicity control in the terahertz (THz) regime is essential for ultrafast polarization optics, chiral spectroscopy, and polarization‐selective photonic devices, yet remains difficult because most THz chiral systems are structurally fixed or rely on slow external...

Association of Estimated Arterial Stiffness with Collateral Status and Functional Outcome after Endovascular Thrombectomy: A Secondary Analysis of the OPTIMAL-BP Trial

PURPOSE: Estimated pulse wave velocity (ePWV) is a surrogate of arterial stiffness that may influence stroke outcomes and potentially affect collateral circulation. We examined the association of ePWV with collateral status and 3-month functional outcome after successful endovasc...

A simplified and clinically applicable prediction model for early identification of bacteremia in febrile patients with solid tumors in the emergency department

Abstract Background Bacteremia is a serious and potentially life-threatening complication in patients with cancer, requiring prompt recognition and early initiation of treatment. However, early identification of bacteremia in febrile cancer patients presenting to the emergency de...

From Sprain to End-Stage Osteoarthritis: Why Earlier Intervention in Ankle Cartilage Damage Deserves More Attention

➢ Ankle cartilage damage ranges from osteochondral lesions of the talus to end-stage osteoarthritis. End-stage ankle osteoarthritis has been associated with a health burden comparable with that of major chronic diseases such as congestive heart failure and kidney disease, while p...

RhoA Y42C drives cell plasticity and PD-1-mediated immune evasion of diffuse gastric cancer

Diffuse gastric cancer (DGC) is an aggressive gastric cancer subtype with a poor prognosis. The RHOA Y42C mutation is recurrent in DGC, but its independent oncogenic role is unclear. Next-Generation Sequencing of 431 DGC cases revealed that most RHOA mutations occurred without CD...

Trajectories of Albuminuria and Non‐Albumin Proteinuria After Sequential Addition of Finerenone for Residual Albuminuria Despite Established SGLT2 Inhibitor Therapy in Diabetic Kidney Disease: A Real‐World Cohort Study

ABSTRACT Aims CONFIDENCE evaluated simultaneous initiation of finerenone and an SGLT2 inhibitor (SGLT2i). We examined 12‐month trajectories of albuminuria and non‐albumin proteinuria after finerenone was added to established SGLT2i therapy. Materials and Methods This single‐centr...

Comparison of Neurophysiological Characteristics Using Heart Rate Variability Between Patients With Korean Hwa-byung and Healthy Individuals

Objective Hwa-byung (HB) is a syndrome associated with stressful events within Korea’s social and cultural contexts. The clinical symptoms of HB may be associated with autonomic imbalance. This study investigated the neurophysiological characteristics of HB by comparing heart rat...

Stereotactic body radiation therapy for hepatocellular carcinoma: 2026 expert consensus-based practical recommendation of the Korean Liver Cancer Association

Stereotactic body radiation therapy (SBRT) is a noninvasive, high-precision radiation technique that delivers a high dose to the tumor in a limited number of fractions, typically five or fewer, and is increasingly used as a curative-intent option for hepatocellular carcinoma (HCC...

Summary of Research: HER2CLIMB-05: A Phase III Study of Tucatinib Versus Placebo in Combination with Trastuzumab and Pertuzumab as First-Line Maintenance Therapy for HER2+ Metastatic Breast Cancer

This is a summary of a research article reporting the findings of the HER2CLIMB-05 trial (NCT05132582), a randomized, double-blind, placebo-controlled, international, phase III trial. The HER2CLIMB-05 trial was conducted to compare the efficacy and safety of adding tucatinib vers...

Generation and Preservation of Submarine Terraces: Insights From Records Imprinted on the Topography of Dokdo Volcano

Abstract Marine terraces archive sea‐level and tectonic history, yet their relationship to individual highstands remains contentious. While most studies focus on subaerial terraces in uplifting settings, submerged terraces in subsiding settings are less explored. We develop a 1‐D...

Deep learning–based automated cervical length measurement improves spontaneous preterm birth risk stratification in women with a borderline short cervix (20–25 mm) at mid‐trimester: A retrospective cohort study

Abstract Objective This study evaluates whether deep learning (DL)‐based automated cervical length (CL) measurement provides improved risk stratification for spontaneous preterm birth (PTB), compared with conventional CL measurement methods, in women with a borderline short cervi...

Rapid progression of coronary atherosclerosis across glycemic status: a serial coronary computed tomography angiography study from the PARADIGM registry

Rapid progression of coronary atherosclerosis is associated with an increased risk of future adverse cardiovascular events. However, evidence regarding the association between glycemic status and rapid plaque progression (RPP) in the major epicardial coronary arteries remains lim...

Stereotactic body radiation therapy for hepatocellular carcinoma: 2026 expert consensus-based practical recommendation of the Korean Liver Cancer Association

Stereotactic body radiation therapy (SBRT) is a noninvasive, high-precision radiation technique that delivers a high dose to the tumor in a limited number of fractions, typically five or fewer, and is increasingly used as a curative-intent option for hepatocellular carcinoma (HCC...

Quantitative Analysis of Automatically Segmented Perivascular Space in Subcortical White Matter of Parkinson’s Disease: Its Clinical Relevance

Objective: To examine the relationship between automatically quantified perivascular space (PVS) extent located in the subcortical white matter (WM), baseline motor deficits and cognitive function, as well as longitudinal motor and cognitive outcomes in patients with Parkinson's...

Subsurface fault imaging beneath the Seoul metropolitan area using joint inversion of S-wave travel times and Rayleigh-wave dispersion

Constraining seismogenic fault structures is critical in the densely populated area such as the Seoul metropolitan area of the Korean Peninsula, where historical records document damaging earthquakes. Recent increase in clustered seismicity has highlighted the need for improved c...

Data-driven personalization of just-in-time adaptive mental health intervention via two-stage reinforcement learning approach

Most digital mental health interventions still deliver uniform content, without accounting for how a user’s fluctuating psychological state interacts with their stable individual characteristics. We propose a two-stage offline reinforcement learning (RL) framework, trained on dat...

Development of an artificial intelligence model for predicting cardiovascular disease in MASLD

Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with cardiovascular disease (CVD). Conventional CVD risk scores often fail to reflect MASLD-specific factors. We aimed to develop and validate an artificial intelligence (AI) model for 10-year CVD risk...

Factors associated with the health-related quality of life of adolescents with atopic dermatitis in South Korea: a cross-sectional study

PURPOSE: Atopic dermatitis (AD) in adolescents has received less attention than AD in infants and children. However, AD can persist or worsen after school age and affect health-related quality of life (HRQoL) beyond adolescence. This study aimed to examine HRQoL and its associate...

Risk and protective factors for the intergenerational transmission of child maltreatment in South Korea: a secondary analysis of data from the Family with Children’s Life Experience Survey

PURPOSE: This study aimed to identify ecological risk and protective factors associated with membership in latent classes characterized by heterogeneous associations between parental adverse childhood experiences (ACEs) and the intergenerational transmission of child maltreatment...