Yokohama City University Medical Center

Patients with neuroendocrine neoplasms referred to the palliative care teams of tertiary care centers: a multicenter retrospective descriptive study

Neuroendocrine neoplasms (NENs) can be divided into well-differentiated neuroendocrine tumors and poorly differentiated carcinomas (NETs and NECs, respectively). Although the incidence of NENs is increasing globally, reports on palliative care in affected populations are scarce....

Lactate dehydrogenase-to-lymphocyte ratio predicts overall and progression-free survival among patients with advanced small-cell lung cancer receiving first-line chemoimmunotherapy

Platinum plus etoposide combined with programmed death-ligand 1 (PD-L1) inhibitors is the standard first-line therapy for patients with advanced small-cell lung cancer (SCLC). However, reliable prognostic biomarkers are yet to be identified. The lactate dehydrogenase-to-lymphocyt...

Piezo1–Src signaling rapidly disrupts brain endothelial barrier integrity

Abstract Background Blood-brain barrier integrity is essential for central nervous system homeostasis, yet the mechanisms underlying ultra-acute barrier dysfunction after abrupt hemodynamic changes remain incompletely understood. Piezo1 is a mechanosensitive Ca²⁺ channel expresse...

Two stress-responsive kinases suppress ferroptosis by activating antioxidant programs under mild oxidative stress

Cancer cells maintain chronically elevated levels of reactive oxygen species (ROS) while relying on robust antioxidant programs to preserve redox homeostasis and viability. Although therapeutic strategies that disrupt this balance to induce lethal oxidative stress and ferroptosis...