Yokohama City University Hospital

Effects of eye movement training on balance and ocular motor function in community-dwelling Japanese school-aged children: a pilot study using a single-group intervention

Eye-movement training (ET) has been proposed as a way to support balance, but its feasibility and long-term effects in children are unclear. We evaluated a 24-week home-based ET program, delivered via the SUKUBARA® video system, in community-dwelling school-aged children, focusin...

Feasibility of an exercise intervention for chemotherapy-related fatigue in patients with gynecologic cancer: a randomized controlled trial with multidimensional assessment

Although exercise interventions have shown benefits in several cancer populations, evidence during chemotherapy for gynecologic cancers remains limited. This randomized controlled trial evaluated the feasibility and efficacy of a home-based exercise intervention for cancer-relate...

Implementing regional care coordination through patient trust, health literacy, and experience: a path analysis of reverse referral preference

Abstract Background “Reverse referral” refers to transferring outpatient care from a large hospital to a community clinic, small hospital, or primary care physician when specialized hospital care is no longer needed. It is key to functional differentiation among medical instituti...

Patients with neuroendocrine neoplasms referred to the palliative care teams of tertiary care centers: a multicenter retrospective descriptive study

Neuroendocrine neoplasms (NENs) can be divided into well-differentiated neuroendocrine tumors and poorly differentiated carcinomas (NETs and NECs, respectively). Although the incidence of NENs is increasing globally, reports on palliative care in affected populations are scarce....

An N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation

Heterozygous carboxyl-terminal variants in the RHO guanosine triphosphatase (GTPase) CDC42 are known to cause severe autoinflammatory syndromes. Here, we identified a heterozygous amino-terminal p.T43I (Thr 43 →Ile) CDC42 variant in patients with autoinflammation and uncovered a...