Yokohama City University

A ruptured internal carotid artery blood blister-like aneurysm with rebleeding after single-layer neck-bridging stenting and complete obliteration after double-layer stenting: A case report

Background: Blood blister-like aneurysms (BBAs) are difficult to treat surgically, and an established treatment strategy is yet to be determined. Treatment options are limited in cases where direct surgery is difficult, and endosaccular embolization is considered infeasible. Case...

2026 revised CVIT clinical expert consensus on drug coated balloons for coronary artery disease

Abstract Drug-coated balloons (DCBs) are attracting attention as a therapeutic alternative to drug-eluting stents (DES) in percutaneous coronary interventions. DCB technology allows direct delivery of antiproliferative drugs to the vessel wall without implantation of a permanent...

High Expression of Aurora Kinase A (AURKA) is Associated with Aggressive Tumor Biology and Therapeutic Response in ER+/HER2− Breast Cancer

Abstract Background Aurora kinase A ( AURKA ) is a serine/threonine kinase that regulates mitotic entry, spindle assembly, and chromosomal segregation. AURKA overexpression has been linked to multiple malignancies. The biological and clinical significance of AURKA expression with...

Development of YO-01027-Derived Signal Peptide Peptidase Inhibitors with Reduced γ-Secretase Inhibition

Abstract Signal peptide peptidase (SPP) is an endoplasmic-reticulum intramembrane aspartyl protease required for hepatitis C virus (HCV) core protein maturation, but many SPP inhibitors also inhibit γ-secretase. Here, we designed YO-01027-derived dibenzazepinone analogs to retain...

Treatment Outcomes for Gastric Cancer With Positive Peritoneal Lavage Cytology or Localized Peritoneal Metastasis

Importance In the era of modern systemic chemotherapy, the optimal treatment strategy for gastric cancer with positive peritoneal lavage cytology (CY1) and/or localized peritoneal metastasis (P1a) remains controversial. Objective To explore the optimal treatment strategy for pati...

Survival Results by the Prospectively Determined Clinical Staging for Locally Advanced Gastric Cancer: A Follow‐Up Study of JCOG1302A

ABSTRACT Background Long‐term overall survival (OS) of gastric cancer stratified by the prospectively determined clinical stage remains unclear. Methods This is an ancillary study of JCOG1302A, a prospective observational study that evaluated the accuracy of clinical diagnosis of...

Cesarean delivery and overweight at 6 years of age: a prospective cohort analysis of the Japan Environment and Children’s Study

Abstract Cesarean delivery (CD) has been suggested as a potential risk factor for childhood overweight and obesity; however, evidence beyond early childhood remains inconsistent. We examined the association between CD and childhood overweight at age 6 years and explored early lif...

Surgical Indications for Type II Thyroplasty in Adductor Spasmodic Dysphonia: A Scoping Review

ABSTRACT Objective This scoping review mapped evidence on surgical eligibility criteria, efficacy, durability, and safety of Type II thyroplasty with titanium bridges for adductor spasmodic dysphonia to identify gaps and inconsistencies among studies and propose preliminary inter...

Anatomical and Histologic Response to Neoadjuvant Therapy: Recurrence Patterns Among Poor Responders. A Multi-institutional Observational Cohort Study.

OBJECTIVE: To characterize the prognostic implications after hepatectomy for colorectal liver metastases (CRLM) by integrating anatomical response to neoadjuvant therapy (NAT), quantified using the Tumor Burden Score ratio (TBSr), with histologic response assessed by Tumor Regres...

A multicenter multistate modeling on the natural history of liver decompensation: Longitudinal analysis of 1777 patients.

BACKGROUND: Cirrhosis often remains silent until decompensation, after which survival deteriorates sharply. Contemporary, transition-aware estimates are limited, especially in Asian-predominant cohorts. We analyzed trajectories from compensated advanced chronic liver disease (cAC...

Impact of third-party accreditation and general medicine in-training examination participation on residency program popularity: a nationwide matching data analysis in Japan

Abstract Background Third-party accreditation and the visibility of educational outcomes may influence medical students’ choice of training sites; however, national evidence of their effect in Japan is limited. This study examined whether hospital characteristics—especially Japan...

Dual northward overseas radiation from Japanese islands shaped the phylogeography of North-East Asian tree frog

The tree frog Dryophytes japonicus has a broad geographic distribution in northeastern Asia, comprising two major genetically divergent clades whose geographic boundary is located within the Japanese mainland. However, the evolutionary and adaptive mechanisms underlying this wide...

Volume‐based stereotactic radiofrequency thermocoagulation for focal cortical dysplasia: A potentially safer alternative to resection in insulo‐opercular and central regions

Abstract Objective Deep white matter infarction caused by injury to the medullary arteries is a crucial cause of postoperative neurological deficits following surgical resection of focal cortical dysplasia (FCD) in the central and insulo‐opercular cortices. Volume‐based radiofreq...

Lateral Tibial Posterior Slope Induces Anterior Tibial Translation While Lateral-Medial Slope Difference Induces Internal Rotation: A Cadaveric Biomechanical Study

Background: Posterior tibial slope (PTS) influences tibiofemoral kinematics and anterior cruciate ligament (ACL) function. While previous studies have evaluated symmetrical slope modifications, the isolated influences of the medial or lateral PTS remain unclear. This study invest...

Effects of eye movement training on balance and ocular motor function in community-dwelling Japanese school-aged children: a pilot study using a single-group intervention

Eye-movement training (ET) has been proposed as a way to support balance, but its feasibility and long-term effects in children are unclear. We evaluated a 24-week home-based ET program, delivered via the SUKUBARA® video system, in community-dwelling school-aged children, focusin...

Mid-term effects of opening wedge high tibial osteotomy on coronal alignment and osteoarthritis progression in the ankle joint: a comparison with total knee arthroplasty

This study aimed to investigate whether knee alignment changes after opening wedge high tibial osteotomy (OWHTO) affect ankle alignment and ankle osteoarthritis (OA) progression, compared to total knee arthroplasty (TKA) in the mid-term. This retrospective study included 72 knees...

Epigenetic Regulation of Sialyltransferase ST6GAL1 Drives Breast Tumor Heterogeneity

Background/Objectives: Tumor progression is often accompanied by sialylation of cell-surface N-glycan glycoproteins with α2-6-linked sialic acids by the sialyltransferase ST6GAL1. Moreover, a hallmark of human cancers is heterogeneity in ST6GAL1 expression among cancer cells, yet...

Feasibility of an exercise intervention for chemotherapy-related fatigue in patients with gynecologic cancer: a randomized controlled trial with multidimensional assessment

Although exercise interventions have shown benefits in several cancer populations, evidence during chemotherapy for gynecologic cancers remains limited. This randomized controlled trial evaluated the feasibility and efficacy of a home-based exercise intervention for cancer-relate...

Implementing regional care coordination through patient trust, health literacy, and experience: a path analysis of reverse referral preference

Abstract Background “Reverse referral” refers to transferring outpatient care from a large hospital to a community clinic, small hospital, or primary care physician when specialized hospital care is no longer needed. It is key to functional differentiation among medical instituti...

Efficacy of Cold-Stimulus Interventions for Thirst Management in Adult Postoperative Patients: A Systematic Review Protocol

Background/Objectives: Postoperative thirst is a common and distressing symptom among surgical patients; however, standardized management guidelines remain limited. Oral care interventions using cold stimulation (e.g., ice chips, popsicles, and menthol-infused products) may relie...