Yokohama City University

Generalizing molecular design via flexible search space control

Abstract Recent advances in generative artificial intelligence have made in silico molecular design a powerful approach for exploring chemical space toward specific goals. However, despite the need for trial-and-error adjustment of generative strategies and reward formulations, m...

Perioperative Cognitive Decline in Verbal Associative Memory Following Carotid Revascularization and Subsequent Risk of Adverse Events: Clinical Significance of the Standard Verbal Paired Associate Learning Test (S-PA)

Background/Objectives: This study aimed to explore whether perioperative changes in cognitive function following carotid artery revascularization, including carotid endarterectomy (CEA) and carotid artery stenting (CAS), are associated with subsequent clinical outcomes, focusing...

Patients with neuroendocrine neoplasms referred to the palliative care teams of tertiary care centers: a multicenter retrospective descriptive study

Neuroendocrine neoplasms (NENs) can be divided into well-differentiated neuroendocrine tumors and poorly differentiated carcinomas (NETs and NECs, respectively). Although the incidence of NENs is increasing globally, reports on palliative care in affected populations are scarce....

The Clinicopathological Characteristics and Prognosis of Cholangiolocarcinoma: A Multicenter Study With a Central Pathology Review

BACKGROUND: Cholangiolocarcinoma (CLC) is a rare liver cancer with ≥ 80% ductular configuration (DC). Given its rarity, its clinicopathological characteristics remain poorly understood, and its status as a distinct disease entity remains controversial. We conducted a nationwide m...

Lactate dehydrogenase-to-lymphocyte ratio predicts overall and progression-free survival among patients with advanced small-cell lung cancer receiving first-line chemoimmunotherapy

Platinum plus etoposide combined with programmed death-ligand 1 (PD-L1) inhibitors is the standard first-line therapy for patients with advanced small-cell lung cancer (SCLC). However, reliable prognostic biomarkers are yet to be identified. The lactate dehydrogenase-to-lymphocyt...

Piezo1–Src signaling rapidly disrupts brain endothelial barrier integrity

Abstract Background Blood-brain barrier integrity is essential for central nervous system homeostasis, yet the mechanisms underlying ultra-acute barrier dysfunction after abrupt hemodynamic changes remain incompletely understood. Piezo1 is a mechanosensitive Ca²⁺ channel expresse...

Visualizing diagnosis-associated AMPA receptor-related [11C]K-2 PET SUVR patterns across psychiatric disorders using weakly supervised UMAP

AMPA receptors (AMPARs) mediate fast excitatory neurotransmission and play a central role in synaptic function, with accumulating evidence in psychiatric disorders. Using [ 11 C]K-2 PET to assess AMPAR-related signals in vivo, we examined whether regional standardized uptake valu...

An N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation

Heterozygous carboxyl-terminal variants in the RHO guanosine triphosphatase (GTPase) CDC42 are known to cause severe autoinflammatory syndromes. Here, we identified a heterozygous amino-terminal p.T43I (Thr 43 →Ile) CDC42 variant in patients with autoinflammation and uncovered a...

Potential EnergySurfaces of Environment-SensitiveFlapping Fluorophores: FLAP

Abstract A series of FLAP molecules are one of the functional fluorescent probes that can sense subtle changes in local environments such as viscosity, polymer free volume, and external mechanical force. In this work, potential energy surfaces (PESs) of a representative Flexible...

The association of corporate measures and health management initiatives with employee engagement in Japanese companies

Using data from 2,502 companies in Japan’s Health and Productivity Management Survey, this study examined determinants of employee engagement and corporate success. Regression analysis showed that hourly paid leave (adjusted odds ratio [aOR]: 1.29, 95% CI: 1.07–1.56) and communic...

Two stress-responsive kinases suppress ferroptosis by activating antioxidant programs under mild oxidative stress

Cancer cells maintain chronically elevated levels of reactive oxygen species (ROS) while relying on robust antioxidant programs to preserve redox homeostasis and viability. Although therapeutic strategies that disrupt this balance to induce lethal oxidative stress and ferroptosis...

Halicin‑Rifampicin Combinations Are More Effective Than Monotherapy Against Biofilm‑Residing Staphylococcus Aureus and Prevent Emergence of Rifampicin Resistance

Background: Biofilms shield bacteria from immune defenses and antibiotics, contributing to implant-associated infections, particularly those caused by Staphylococcus aureus (S. aureus). Halicin, a repurposed antimicrobial with broad-spectrum activity, has shown promise against pl...