Yinchuan First People's Hospital

Study on the role and mechanism of CIH-activated ferroptosis in secondary cognitive impairment due to OSAHS

Objective This study investigates whether chronic intermittent hypoxia (CIH) induces cognitive deficits through IL-6/hepcidin-mediated ferroptosis in patients and animal models with obstructive sleep apnea-hypopnea syndrome (OSAHS). Clinical and animal research demonstrates that...

Prohibitin 1 orchestrates mitochondrial-ER crosstalk via the VDAC1-GRP75-IP3R axis to drive malignancy in gastric cancer

<title>Abstract</title> <bold>Background</bold>: Mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), serving as critical hubs for mitochondrial- ER interactions, play a pivotal role in cancer progression. Prohibitin 1 (PHB1), an inner mitochondrial membrane prote...

Latent Profiles of Post-Stroke Fatigue and Their Association with Anxiety, Depression, and Sleep in Patients with First-Ever Stroke: A Cross-Sectional Study

Objectives: This study aimed to identify latent profiles of post-stroke fatigue (PSF) and examined their associations with anxiety symptoms, depressive symptoms, and sleep quality among first-ever stroke survivors. Methods: From December 2023 to May 2024, participants were recrui...