Yichang Central People's Hospital

Analysis of care needs for primary caregivers of premature infants at home based on the Kano model: A cross-sectional study

Objective This study applied the Kano model to analyze the attributes of care needs among primary caregivers of discharged premature infants(up to 6 months post discharge), identify priority needs, and provide a foundation for developing targeted nursing service plans. Methods Be...

Oral small-molecule GLP-1 receptor agonist safiglipron in early type 2 diabetes: a randomized, double-blind, placebo-controlled trial

Abstract Safiglipron is an oral small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist administered without fasting or dietary restrictions. We evaluated its efficacy and safety in OUTSTAND-1, a phase 3, multicenter, randomized, double-blind, placebo-controlled trial at...

Therapeutic targeting of the SLC39A13-AS1/TCF20/RUNX1 axis inhibits glutamine metabolism and ovarian cancer progression

“Glutamine addiction” is among the key features of tumor metabolic reprogramming and is an important target for tumor therapy. Unfortunately, the mechanisms underlying the abnormal expression of genes related to glutamine metabolism in ovarian cancer (OC) remain unclear. Here, we...

Integrated nail plate construct for the management of complex distal femoral fractures in older patients

The management of distal femoral fractures (DFF) in older patients is challenging due to complex fracture patterns and osteoporosis. No consensus has yet been established on the optimal internal fixation strategy for DFF. Therefore, our research aimed to evaluate the clinical eff...

Association of C-reactive protein-triglycerides-glucose index-waist-to-height ratio with mortality in metabolic dysfunction-associated steatotic liver disease (MASLD): evidence from two cohort studies

Abstract Background MASLD significantly increases the risk of cardiovascular events and all-cause mortality (ACM). The impact of the C-reactive protein-triglyceride-glucose index (CTI) and its derivatives on mortality in the MASLD population remains unclear. This study aimed to i...

A structural cardiac pathway mediates the risk of ischemic heart disease from TyG-related indices: A prospective cohort study

The triglyceride-glucose (TyG) index and its derivatives are surrogate markers of insulin resistance and are closely associated with cardiovascular risk. However, whether and to what extent they are associated with IHD risk through subclinical cardiac remodeling remains unclear....

Targeted degradation of RAGE restores microglial homeostasis and rescues cognitive deficits in 3xTg-AD mice

Chronic neuroinflammation and microglial dysfunction lie at the core of Alzheimer’s disease (AD) pathogenesis. The Receptor for Advanced Glycation End-products (RAGE) serves as a pivotal upstream driver of this inflammatory cascade and associated oxidative stress. However, conven...

Gallstone formation and hepatobiliary tumour risk: Clinical implications of the bile acid–gut microbiota axis

Abstract Background Gallstones affect approximately 6%–15% of adults worldwide and represent a common condition that also serves as a risk factor for hepatobiliary malignancies. Conventional ultrasound cannot provide early warning during the early metabolic phase before crystalli...

Reprogramming pulmonary B cells by ANXA1 silencing halts lung metastatic niche formation in breast cancer

Lung metastasis remains a determinant of poor prognosis and survival in breast cancer and is understood to depend on a permissive pulmonary immune niche rather than tumor cell traits alone. Here, we developed a host-directed RNA interference strategy to modulate this niche by rep...

Pop Rocks-Inspired Bubble Driven Exosome Propulsion via Microneedles for Synergistic Wound Healing

Abstract Chronic nonhealing wounds remain a critical clinical challenge due to persistent bacterial infection, tissue hypoxia, and impaired cellular regeneration. Herein, inspired by the “popping” mechanism of Pop Rocks candy, we developed a multifunctional microneedle (MN) patch...

Tannic acid-modified MoS 2 /silk fibroin hydrogel photothermal antibacterial synergistic macrophage M2 polarization regulation for the treatment of diabetic ulcers

Diabetic ulcer treatment is complicated by bacterial infections and immune microenvironment dysregulation. This study developed a multifunctional composite hydrogel by non-covalently functionalizing molybdenum disulfide with tannic acid and integrating it with silk fibroin. The r...