Yangpu Hospital of Tongji University

Rhein-induced free fatty acid generation cooperates with silver ions for biofilm-infected diabetic wound healing

Diabetic foot infection (DFI) significantly increases the risks of hospitalization and amputation, with biofilm infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Escherichia coli (CREC) being key drivers of treatment failure. Here, w...

UBE2K-FBXO11 complex activates Wnt signaling by stabilizing β-catenin through lysine 63-linked polyubiquitination

Abstract Β-catenin is regulated by phosphorylation and lysine (K)48-linked ubiquitination, which target it for proteasomal degradation. While the degradation machinery of β-catenin, including the destruction complex, has been extensively studied, regulators that stabilize β-caten...

Sleep-disordered breathing is associated with Blood-brain barrier markers across the Alzheimer’s disease spectrum

Sleep-disordered breathing (SDB) is prevalent among older adults and is increasingly recognized as a modifiable risk factor for cognitive decline and Alzheimer’s disease (AD). Blood-brain barrier (BBB) dysfunction is an early and mechanistically relevant feature of AD pathophysio...

Research on the Mechanism by Which Lysophosphatidylcholine Regulates the Inflammatory Response in Ischemic Stroke Through the NF-κB Signaling Pathway

Background: Neuroinflammation following ischemic stroke is a significant factor leading to secondary brain damage, but the role of lysophosphatidylcholine (LPC) in this process remains unclear. This study sought to determine whether LPC participates in the post-ischemic inflammat...

Smart Implant Coating with Pathological-Microenvironment-Driven Drug and Nanozyme Delivery for Osteoporotic Bone Healing

Stimuli-responsive drug delivery from orthopedic implants holds particular promise for enhancing osseointegration in osteoporotic bone. However, challenges such as the lack of feedback-regulated functionality and microenvironmental modulation persist. Here, we developed an osteop...

METTL3-mediated m6A modification of TP73-AS1 enhances HCC progression by activating Wnt/β-catenin signaling

Long noncoding RNAs (lncRNAs) play key roles in the onset and progression of hepatocellular carcinoma (HCC). Tumor protein 73 antisense RNA 1 (TP73-AS1), a recently identified lncRNA, has been implicated in cancer occurrence, drug resistance, and prognosis; however, its function...

Risk factors for acute ischemic stroke of small vessel occlusion in elderly patients with cerebral small vessel disease and establishment of a prediction model

Cerebral small vessel disease (CSVD) accounts for 25% of ischemic stroke causes, yet risk factors for acute ischemic stroke (AIS) in elderly CSVD patients remain unclear. This study aimed to identify these risk factors and establish a prediction model. This single-center retrospe...

Institutional complexity and entrepreneurial work in grassroots cultural heritage: Evidence from Hanfu entrepreneurship in China

Abstract Cultural heritage entrepreneurship (CHE) often requires entrepreneurs to reconcile authenticity claims with commercial imperatives. This challenge is especially pronounced in grassroots heritage revivals where heritage meanings are contested and cultural authority is une...

From intravascular imaging to adaptive vascular care: intelligent photonics and digital twins in panvascular disease

Panvascular diseases (PVDs) stand as the leading cause of global mortality, necessitating a paradigm shift from local anatomical repair to the systemic restoration of vascular homeostasis. While intravascular optical imaging has revolutionized diagnosis, it remains a passive obse...