Yancheng Second People's Hospital

A novel ATP7A splice‑site variant with suspected maternal gonadal mosaicism in Menkes disease: functional validation and prenatal diagnosis

Abstract Menkes disease (MIM#309400) is a rare, fatal X-linked neurodegenerative disorder caused by ATP7A mutations. Delayed diagnosis due to clinical heterogeneity and limited data on mutational spectrum and reproductive risk remain challenges, with gonadal mosaicism being an of...

The effect of epidural analgesia with hydromorphone combined with ropivacaine on intrapartum fever in women undergoing vaginal delivery

Epidural-related maternal fever (ERMF) is a well-recognised complication of epidural labor analgesia, with a significantly higher incidence compared to parturients who do not receive epidural analgesia. We hypothesised that hydromorphone combined with ropivacaine during epidural...

PediatricLiver score: a novel risk score for screening elevated liver stiffness in the pediatric population (CHESS2401)

Given the looming crisis of rapid increase in childhood obesity globally, chronic metabolic diseases have consequently emerged but without sufficient awareness among children. Reliable and accessible screening tools thus are required to screen for significant liver fibrosis in th...

Influenza-associated Benign Acute Childhood Myositis

Background: To characterize the severity, clinical course, and 6-month outcomes of influenza-associated benign acute childhood myositis (BACM) during the 2024–2025 season and to explore differences between cases associated with influenza A and B. Methods: We retrospectively analy...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...