Yancheng First People's Hospital

Correlation analysis between cerebrovascular intervention therapy and perioperative blood pressure variability and cerebral blood flow reserve in elderly patients with intracranial artery stenosis

To explore the correlation between neurological function prognosis, perioperative blood pressure variability (BPV), and the change rate of cerebral blood flow velocity (CBFV) in elderly patients with intracranial arterial stenosis (ICAS) undergoing cerebrovascular intervention th...

Macrophage-mimetic liposomal nanovesicles deliver CXCR2 antagonists to suppress CXCL2-driven breast cancer and atherosclerotic progression

The coexistence of breast cancer (BC) and atherosclerosis (AS) is increasingly recognized as an inflammation-driven comorbidity. This study identifies the CXCL2–CXCR2 signaling axis as a pivotal mechanistic link underlying both diseases and introduces a macrophage-mimetic nanopla...

Circulating miR-106b-5p discriminates acute myocardial infarction patients, predicts disease severity, and regulates H/R-induced cardiomyocyte injury by targeting CDKN1A

The early detection, disease monitoring, and prognosis prediction are of great significance for acute myocardial infarction (AMI). This study focused on miR-106b-5p, evaluating its clinical significance in AMI onset and progression. This study enrolled 147 AMI patients with 123 s...

CT quantification of enlarged inguinal lymph nodes as a diagnostic approach for periprosthetic joint infection after hip arthroplasty

Periprosthetic joint infection (PJI) is a major complication following total hip arthroplasty (THA), posing significant diagnostic challenges. This study prospectively evaluated 114 patients from January 2021 to August 2023, including those with PJI and aseptic loosening, using c...

Waldenstrom’s macroglobulinemia in siblings: a single institutional experience with 10 cases at 25 years and a review of the literature

Waldenstrom’s macroglobulinemia (WM) is characterized by familial aggregation. The study displayed the characteristics and outcomes of patients with WM in siblings. Ten cases (five pairs) were recognized as WM in siblings. The earliest pair (cases 3 and 4) was identified in 2002...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...