Yan'an University

From chemical oscillators to biological synchrony: a programmable reaction-diffusion model for studying signal coordination in cardiomyocyte networks

Abstract The self-organization of asynchronous rhythms into synchronized beating in in vitro cardiomyocyte networks is a fundamental problem in systems biology research. Inspired by the dynamics of chemical oscillators, this paper presents a programmable model framework based on...

Nonlinear association between maternal depressive symptoms and overreactive parenting among preschool children: a cross-sectional study

Maternal depressive symptoms (MDS) have been associated with negative parenting practices. However, research examining the specific pattern between MDS and overreactive parenting remains limited. Our objective was to comprehensively assess the association between MDS and overreac...

Fingolimod overcomes cisplatin resistance in esophageal squamous cell carcinoma by targeting NUP54 to disrupt homologous recombination repair

Cisplatin resistance is a major obstacle in the treatment of esophageal squamous cell carcinoma (ESCC). To address this challenge, we screened a U.S. Food and Drug Administration (FDA)-approved drug library and identified fingolimod, an immunomodulatory agent, as a potent inhibit...