Yamaguchi University

Beyond Principlism: A Cosmopolitan and Care Ethics Approach to One Digital Health

Abstract This article examines the limitations of principlism in addressing the ethical challenges posed by One Digital Health. While principlism remains influential in bioethics, digital health, and global health policy, we argue that it is insufficient to capture the relational...

Increased concurrent immunoreactivity of macrophage markers and HSP47 in the uterus of old multiparous cows

CONTEXT: Declining fertility in aging cows is associated with impaired uterine function, but the relationship between immune remodeling and fibrosis-associated uterine changes remains poorly understood. AIMS: We hypothesized that the uterus of old multiparous cows exhibits coordi...

Current Evidence on Late-Onset Hypogonadism in Primary Care: A Scoping Review Protocol

Fatigue, loss of energy, low sexual desire and erectile dysfunction are common in primary care, and late-onset hypogonadism (LOH), defined according to symptoms and low testosterone levels, is one possible explanation. Its symptoms are non-specific, and terminology and diagnostic...

In vivo 3D hip kinematics during racket swinging after total hip arthroplasty

Aims Interest in sports participation after total hip arthroplasty (THA) has grown, and some patients return to playing racket sports after THA. However, dynamic hip kinematics and the risk of liner-to-neck contact during racket swinging remain unclear. This study aimed to evalua...

Mean square estimates for the error terms of sums of the greatest common divisor

Abstract We investigate the mean square behavior of error terms that arise in the summation of gcd ( n 1 , … , n k ) $\gcd (n_1,\ldots ,n_k)$ gcd left parenthesis n 1 comma ellipsis comma n Subscript k Baseline right parenthesis with n 1 … n k ≤ x $n_1\ldots n_k \le x$ n 1 ellips...

Tail-degloving and cold storage facilitate primary cell culture from wild-caught rodents

The use of wild rodents as biological resources is hindered by the difficulties of live transport and primary culture contamination caused by skin bacteria. To address this, we developed a "tail-degloving" method to physically remove the contaminated external integument. Using th...

Hierarchical Electronic Transport in Giant Mixed-Valence {Mo154} Rings Revealed in Anhydrous Single-Molecule-Layer Networks

Abstract Polyoxometalates (POMs) are redox-active metal–oxo clusters of central interest in molecular and materials chemistry. The giant mixed-valence {Mo154} ring, built from 14 repeating subunits, is a prototypical system expected to exhibit rich electronic functionality; howev...

Multiancestry genome-wide association and multiomics analyses elucidate spatiocellular features of multiple sclerosis genetics

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination disseminated in space and time. Here we performed a genome-wide association study (GWAS) using 688 MS cases and 205,199 controls from the Japanese population and...

ABCG transporters are involved in the accumulation of specialized metabolites in the oil bodies of Marchantia polymorpha.

Bioactive specialized metabolites (SMs) are synthesized and sequestered in specific cellular compartments or organelles as a self-defense strategy against their intrinsic toxicity. Liverwort-specific oil bodies accumulate large amounts of SMs and contribute to chemical defense; h...

Distribution and Clinical Utility of the Kidney Disease Improving Global Outcomes Chronic Kidney Disease Risk Classification in Patients Undergoing Atrial Fibrillation Ablation

Background Chronic kidney disease (CKD) is a key component of the cardiovascular–kidney–metabolic framework. However, in patients undergoing atrial fibrillation ablation, the distribution of CKD across Kidney Disease: Improving Global Outcomes risk categories and its prognostic v...

Nuclear Pan‐Lysine Lactylation Immunoreactivity Is Associated With Poor Prognosis in Intrahepatic Cholangiocarcinoma

AIM: Lysine lactylation (Kla) links cellular metabolism to gene regulation, but its significance in intrahepatic cholangiocarcinoma (ICC) remains unclear. METHODS: Nuclear pan-Kla immunoreactivity was evaluated in 118 patients who underwent curative-intent resection for ICC. Asso...

Relationship between initial dose, dose intensity, and survival in unresectable pancreatic cancer treated with nanoliposomal irinotecan, fluorouracil, and folinic acid

Abstract While nanoliposomal irinotecan with fluorouracil and folinic acid (NFF) is a standard second-line regimen for unresectable pancreatic cancer (uPC) after gemcitabine-based therapy, the effects of initial dosing and relative dose intensity (RDI) in routine practice are unc...

A Tert ‐Alkyl Terephthalate Derivative as a Universal Degradable Unit for Condensation Polymers

ABSTRACT Incorporating cleavable triggers into the backbones of parent polymers enables programmed degradation, offering a pathway to chemically recyclable plastics. Although various triggers have been reported to date, simple esters bearing a C─O bond cleavable by photocatalytic...

An intractable case of primary intra-axial central nervous system Rosai–Dorfman disease

Background: Rosai–Dorfman disease (RDD) is a rare histiocytic disorder with a typically benign clinical course. However, isolated involvement of the central nervous system (CNS), particularly in the form of primary intra-axial disease, is exceedingly rare. We report an intractabl...