Yale New Haven Hospital

A Remotely Delivered Exercise-Based Rehabilitation Program for Patients with Persistent Chemotherapy-Induced Peripheral Neuropathy (EX-CIPN): A Phase I Feasibility Trial

Background: Chemotherapy-induced peripheral neuropathy (CIPN) affects two-thirds of patients who receive neurotoxic chemotherapy. In almost half of these patients, CIPN is persistent, with limited treatment options. Exercise-based rehabilitation shows promising results in improvi...

Robot-Assisted Radical Cystectomy with Intracorporeal Urinary Diversion: Perioperative Management and Operative Technique

Radical cystectomy with bilateral pelvic lymphadenectomy and urinary diversion remains the standard of care for muscle-invasive bladder cancer and selected high-risk non-muscle-invasive disease. The procedure carries substantial morbidity, in part because the typical patient is e...

Anticoagulation Treatment Response Among Phenotypic ESUS Clusters: Evidence From CASPR

ABSTRACT Objective To evaluate treatment effect heterogeneity across phenotypic clusters of patients with cryptogenic embolic stroke using causal inference methods. Methods From a retrospective, multicenter cohort of patients with cryptogenic embolic stroke, we estimated the trea...

Anticancer Drugs and Cancer-Associated Thrombosis

The rapid development of novel cancer therapies has considerably improved the care of cancer patients and cancer-related survival; however, these therapies are associated with a broad range of adverse events that have become a major burden in this population. Alongside other canc...

Association of Race/Ethnicity on Resolving Inactive Kidney Transplant Status Prior to COVID-19

Introduction Minority waitlisted kidney patients are less likely to resolve an inactive status change. We investigate race/ethnicity-based differences in the reasons for and resolution of waitlist inactivation. Methods The Organ Procurement and Transplantation Network database wa...

Association between intravenous phosphate repletion and serum phosphate relative to enteral repletion in hospitalized adults: A retrospective cohort study

BACKGROUND: Enteral phosphate repletion may reduce the need for fluid replacement, decrease costs, and minimize waste. Enteral repletion has been previously shown to be noninferior to intravenous (IV) repletion. The primary objective of this study was to evaluate the association...

From Ionic Agitation to Precision Neuroablation: A Bioengineering Perspective on the Mechanisms, Modalities, and Clinical Applications of Radiofrequency Technology in Pain Management

Radiofrequency ablation (RFA) is a foundational interventional technology in pain management. Despite the diversity of available systems, conventional thermal, internally cooled, bipolar, and pulsed radiofrequency (PRF) all share one biophysical mechanism: high-frequency alternat...

Voices From the Community: How Inpatient Clinicians Experience Caring for Deteriorating Children

BACKGROUND: National initiatives to improve care for children in community emergency department settings have demonstrated improved quality with decreased pediatric mortality. In contrast, pediatric readiness for inpatient care in community hospitals remains poorly defined. Carin...

Missed Opportunities for Stroke Prevention in Patients With Hypertension: A Retrospective Case–Control Study

BACKGROUND: Hypertension is the leading modifiable risk factor for ischemic stroke, yet the adequacy of preventative hypertension care in routine clinical practice remains suboptimal, potentially representing missed opportunities for stroke prevention. We evaluated the associatio...

New Technology for the Treatment of Bone Defects and Limb Length Discrepancies with a Motorized Intramedullary Bone Transport Nail

SUMMARY: Bone defects are among the most challenging problems treated by limb reconstruction surgeons and orthopaedic traumatologists. Bone transport is a biological reconstruction technique which harnesses distraction osteogenesis to create new bone in critical bone defect. This...

An Endovascular Approach for Idiopathic Intracranial Hypertension: Assessing Morphometric Candidacy After Venous Sinus Stenting

BACKGROUND AND OBJECTIVE: Current treatments of idiopathic intracranial hypertension (IIH), a disorder of elevated intracranial pressure, include ventriculoperitoneal shunting and venous sinus stenting (VSS). Recently, transvenous endovascular shunting using the CereVasc eShunt s...

Endovascular Stroke Thrombectomy for Patients With Concomitant Head Trauma: A Propensity Score–Matched and Machine Learning Study

BACKGROUND: The safety and efficacy of endovascular thrombectomy (EVT) for patients with large vessel occlusion stroke presenting with concomitant head trauma is unclear. METHODS: Using the Nationwide Readmissions Database in the United States (2016–2022), we identified adults wi...

Comparison of Empiric Antibiotics With and Without MRSA Coverage in Staphylococcal Scalded Skin Syndrome

PURPOSE: Treatment of staphylococcal scalded skin syndrome (SSSS) typically covers methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA). However, limited data exist to show an optimal antibiotic regimen. We hypothesized that empiric antibi...

Secondary use and scholarly impact of a portfolio of clinical trials with shared individual participant level data: cross sectional study

Abstract Objective To assess the number, timing, characteristics, and scholarly impact of secondary publications generated using individual participant level data (IPD) from a portfolio of clinical trials shared with external investigators through a data sharing platform. Design...

Variation in meningioma recurrence risk estimates across observational cohorts: the influence of calendar time, WHO classifications, geographical settings, and healthcare systems

Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...

Impact of ethyl alcohol nasal treatment on hospital-onset Staphylococcus aureus bacteremia at a tertiary health system

Abstract Introduction: Staphylococcus aureus is a common pathogen that can cause nosocomial infection. Ethyl alcohol has emerged as a potential alternative to mupirocin and povidone-iodine for nasal decolonization; however, data on real-world application are limited. Methods: A q...

Cardiovascular Risk Prediction with the Kidney Failure Risk Equation in the Chronic Renal Insufficiency Study

Background: The Kidney Failure Risk Equation (KFRE) is an established tool to predict the risk of kidney failure among patients with CKD. Patients with CKD more often die from cardiovascular (CV) causes than renal causes, and more often experience a non-fatal CV event than progre...

Perspectives on an Intervention to Increase Confidence in Newborn RSV Immunoprophylaxis

OBJECTIVES Respiratory syncytial virus (RSV) immunoprophylaxis is efficacious, yet uptake is low in comparison with other recommended newborn interventions. We aimed to identify barriers to and enablers of implementation of an intervention in the well newborn unit to increase par...