Xuzhou Central Hospital

SASI compared with SG-JJB for obese diabetic rats: an experimental comparative study on weight reduction, glycemic control, and postoperative complications

To compare the weight loss, glycemic control, and complication rates of three surgical procedures-sleeve gastrectomy combined with single-anastomosis sleeve ileal bypass (SASI), sleeve gastrectomy with jejuno-jejunal bypass (SG-JJB), and sleeve gastrectomy (SG) alone-in obese dia...

Self-assembled products from natural active compounds: mechanisms and applications in cancer therapy

Natural active compounds (NACs) possess diverse anticancer activities but are often limited by poor aqueous solubility, low bioavailability, insufficient tumor selectivity, and inadequate in vivo stability. Self-assembled products from natural active compounds (SAPNACs) provide a...

Body Weight in Relation to the Effectiveness of Intravenous Alteplase in Acute Ischemic Stroke: The ENCHANTED Trial

BACKGROUND: The prognostic significance of body weight in patients receiving thrombolysis for acute ischemic stroke remains uncertain. This study aimed to determine whether body weight modifies the comparative effects of low- versus standard-dose intravenous alteplase and to eval...

miR-892b targeting CTNNB1 regulates sepsis-induced myocardial dysfunction

Numerous sepsis patients experience myocardial damage, leading to a high mortality rate of sepsis. To investigate the clinical and functional role of miR-892b in sepsis-induced myocardial dysfunction (SMD). The expression of miR-892b and CTNNB1 in clinical subjects was measured b...

Evaluation of contrast-enhanced ultrasound-guided fine needle aspiration biopsy in thyroid nodule diagnosis: a study from two tertiary referral centers

PURPOSE: This study aimed to compare the final definitive diagnosis (FDD) rate and accuracy of contrast-enhanced ultrasound (CEUS)-guided fine-needle aspiration biopsy (FNAB) with conventional US-guided FNAB. METHODS: A two-center study was conducted to compare the diagnostic per...

Association Between Lithium Use and Suicide‐Related Behaviors in Bipolar Disorder: A Multicenter Study

BACKGROUND: Lithium has long been associated with reduced suicide risk in bipolar disorder; however, evidence from real-world clinical populations remains susceptible to confounding, and the behavioral correlates related to this association are not well characterized. METHODS: In...

New-onset headache and early aggravation of pre-existing headache after anterior cervical discectomy and fusion: a retrospective cohort study

Pre-existing cervicogenic headache often improves after anterior cervical discectomy and fusion (ACDF); however, new-onset postoperative headache and early aggravation of pre-existing headache remain poorly characterized. This study evaluated these outcomes separately and assesse...

Chronic kidney disease due to hypertension in China, Japan, and the Republic of Korea: trends from the Global Burden of Disease Study 1990–2023

Abstract Objective To evaluate the burden and temporal trends of chronic kidney disease (CKD) attributable to hypertension in China, Japan, and the Republic of Korea from 1990 to 2023 using Global Burden of Disease (GBD) 2023 data. Methods Age-standardized incidence, mortality, a...

Carnosol Accelerates Pressure Ulcer Healing via Keap1-Nrf2/HO-1-Mediated Mitochondrial Quality Control

Abstract Pressure ulcer pathogenesis involves ischemia-reperfusion-induced oxidative stress and mitochondrial dysfunction. Carnosol, a rosemary-derived diterpene with antioxidant properties, was investigated for its therapeutic potential in tissue repair. Carnosol pretreatment pr...

AFF-net: adaptive feature fusion network for efficient medical image segmentation

Medical image segmentation is essential for clinical diagnosis and treatment. Existing convolution and self-attention-based segmentation methods suffer from heavy computational overhead, while complex lesion morphology and blurred anatomical boundaries further degrade segmentatio...

Unicompartmental versus total knee arthroplasty in patients aged 60 years or older with isolated medial knee osteoarthritis and correctable varus deformity > 15° to 20°: a five-year retrospective cohort study

The role of unicompartmental knee arthroplasty (UKA) in patients aged ≥ 60 years with isolated medial knee osteoarthritis and correctable varus > 15° remains controversial. Five-year UKA and total knee arthroplasty (TKA) outcomes were compared in patients with varus > 15° to 20°....

Metabolomics analysis of placenta associated with preterm birth and the function of candidate metabolites on decidual senescence

Preterm birth (PTB) is one of the most common adverse pregnancy outcomes, increasing the risk of both short- and long-term complications in infants. While the exact mechanisms of PTB has not been determined, infection and/or inflammatory responses are closely connected with it. L...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

PD-L1+ exosomes as biomarkers and therapeutic targets in multiple myeloma: implications for CAR-T efficacy and combination immunotherapy

Although chimeric antigen receptor T-cell (CAR-T) therapy has reshaped the treatment landscape for relapsed/refractory multiple myeloma (RRMM), durable remission remains challenging. T-cell dysfunction and exhaustion are key obstacles to long-term efficacy. Programmed death-ligan...

USP2 is associated with mitochondrial respiratory activity and cell viability in endometrial stromal cells in endometriosis

Mitochondrial dysfunction has been implicated in the pathophysiology of endometriosis, but the role of ubiquitin-specific protease 2 (USP2) remains unclear. This study aimed to determine whether USP2 modulates mitochondrial respiratory activity and proliferation in ectopic endome...

Foretinib triggers immunogenic cell death and enhances efficacy of anti-CD47 immunotherapy in colorectal cancer

Dual-target c-Met/VEGFR kinase inhibitors have emerged as promising therapeutic agents for cancer therapy, although their underlying antitumor mechanisms remain poorly defined. In this study, we demonstrate that foretinib, a selective c-Met/VEGFR2 inhibitor, triggers immunogenic...

Serum homocysteine as a novel biomarker for predicting intestinal necrosis in patients with bowel obstruction: a prospective observational study

We evaluated the diagnostic accuracy of serum homocysteine (HCY) for predicting intestinal necrosis in patients with bowel obstruction and compared its performance with conventional inflammatory biomarkers. This prospective observational study enrolled consecutive patients presen...