Xiyuan Hospital

Protective effects of icariin in atherosclerotic cardiovascular disease: mechanistic basis, post-ischemic protection and translational limitations

CONTEXT: Icariin (ICA), a prenylated flavonol glycoside from Epimedii Folium, has been investigated in experimental models relevant to atherosclerosis, myocardial infarction, and ischemic tissue injury. OBJECTIVES: This review evaluates experimental evidence on ICA in atheroscler...

Combining network toxicology with machine learning and experiment validation to analyze the molecular mechanism and core target screening of aristolochic acid nephropathy

Aristolochic acid nephropathy (AAN), a rapidly progressive kidney disease caused by aristolochic acid (AA), frequently progresses to end-stage renal disease and lacks effective therapy. The molecular targets that couple AA exposure to renal injury remain further defined. This stu...

From glucolipotoxicity to cardiorenal injury: mitophagy imbalance in the cardiovascular–kidney–metabolic syndrome continuum

Cardiovascular–kidney–metabolic (CKM) syndrome is a progressive systemic disease driven by the interplay among metabolic abnormalities, chronic kidney disease, and cardiovascular disease. It is characterised by a high prevalence, complex pathophysiological mechanisms, and extensi...

Association Between Rest–Activity Rhythm and Cardiovascular Disease, Cardiovascular Mortality, and All‐Cause Mortality: A Systematic Review and Meta‐Analysis

BACKGROUND: Disruption in rest-activity rhythm (RAR) is an emerging risk factor for cardiovascular disease (CVD) and mortality, but the strength of evidence is unclear. Therefore, we conducted a systematic review and meta-analysis to assess associations between RAR characteristic...

Goblet cell heterogeneity and plasticity in ulcerative colitis: implications for mucus barrier reconstitution

The mucus barrier maintained by intestinal goblet cells is critical for colonic homeostasis, and its disruption is a key pathological hallmark of ulcerative colitis (UC). Goblet cells, once thought to be a homogeneous population of passive mucin secretors, are now recognized as a...

On Multi-Source Sludge Smoldering Process

Abstract Smoldering, as an emerging technology, exhibits significant potential for the efficient disposal of organic solid waste with high moisture content; however, theoretical models targeting multi-source blended fuels remain scarce. This work systematically investigates the s...

Diabetic plaque calcification: mechanisms, imaging phenotypes, and clinical implications

Diabetes is associated with a higher burden and heterogeneous phenotypes of plaque calcification, which may influence plaque stability and cardiovascular risk. This review examines diabetic plaque calcification as a dynamic process driven by hyperglycemia and other metabolic dist...

A MultitaskLarge Reasoning Model for Molecular Science

Abstract Artificial intelligence in molecular science must move beyond pattern recognition toward chemically valid and interpretable reasoning. We present a task-adaptive large reasoning model that integrates chemical knowledge through a synergistic multispecialist architecture,...

Topographic analysis of choroidal thickness in pachychoroid disease using ultra-widefield swept-source optical coherence tomography

Purpose To characterise regional and topographic choroidal thickness (CT) profiles using ultra-widefield swept-source optical coherence tomography (UWF SS-OCT) and to compare topographic CT between normal eyes and eyes with pachychoroid disease. Methods All participants underwent...