Xinqiao Hospital

PIGU expression is associated with poor prognosis and estimated immune cell infiltration in breast invasive carcinoma

Breast invasive carcinoma (BRCA) is a major cause of cancer-related mortality in women. PIGU , a subunit of the GPI-anchor biosynthesis complex, has been reported to be dysregulated in several cancers; however, its prognostic value and immune-related associations in BRCA remain u...

Rapamycin‐nanoliposomes target the mTORC1 ‐mediated autophagy–lysosomal and NLRP3 /Caspase‐1 pathways to inhibit nucleus pulposus cell senescence in intervertebral discs

Abstract Nucleus pulposus (NP) cell quiescence maintains intervertebral disc homeostasis, while mTORC1 regulates autophagy–lysosomal function and inflammatory secretion to preserve quiescence—rapamycin specifically targets mTORC1. Herein, we fabricated rapamycin‐nanoliposomes (ra...

The Multi-Layered Effect of Panaxatriol Saponins in Preventing Diabetic Nephropathy in Mice

Background: Diabetic nephropathy (DN) is a common microvascular complication of diabetes and the leading cause of end-stage renal disease (ESRD). Nearly 40% of people with diabetes will develop DN, and DN accounts for 23% of ESRD cases in China. Dysfunction of the gut-kidney axis...