Xinqiao Hospital

Paraclostridium bifermentans S1-GT1 spores: a novel approach for oncolytic therapy

The core regions of solid tumors are characterized by hypoxia, which limits the efficacy of conventional therapies. Anaerobic bacterialspores represent a promising therapeutic strategy because they can germinate and proliferate in hypoxic regions. This study evaluatedthe antitumo...

Self-perceived knowledge, attitudes, and preventive practices regarding knee ligament injuries among sports enthusiasts

Sports enthusiasts frequently experience knee ligament injuries. This study assessed their self-perceived knowledge, attitudes, and preventive practices regarding such injuries. A cross-sectional study was conducted from December 2025 to January 2026. Demographic information and...

Orthogonal Light‐ and Enzyme‐Triggered and‐Gate Prodrugs for Senolytic Therapy

ABSTRACT Senescence‐associated β‐galactosidase (SA‐β‐gal) is widely used to target senescent cells, but its activity in non‐senescent tissues can limit selectivity. Here, we developed a light–enzyme AND‐gate strategy in which an o‐nitrobenzyl photocage blocks β‐galactoside cleava...

Development and Validation of Daping Orthopedics Operative Risk Scoring System for Geriatric Hip Fracture ( DOORS ‐ GHF ) for Predicting Postoperative Outcomes in Geriatric Hip Fracture Patients: A Multicenter Retrospective Comparative Study

ABSTRACT Objective With China's accelerating population aging, geriatric hip fractures pose a growing clinical challenge. High comorbidity burden and diminished physiological reserve drive elevated postoperative complication and mortality risks in this population. However, most e...

Graph neural network-based service migration decision in vehicular networks

Abstract The rapid development of the Internet of Vehicles (IoV) has led to an exponential increase in the number of latency sensitive and computationally intensive tasks. Due to the limitations of onboard computing resources in vehicles, offloading these tasks generated during v...

Extending the ATP9A ‐Related Phenotypic Spectrum: Indication of Schizophrenia Susceptibility

ABSTRACT ATP9A, which belongs to the P4‐ATPase family of proteins, is involved in the efficient transport of vesicles from the Golgi apparatus to the plasma membrane, as well as the release of extracellular vesicles from human cells. In 2021, a loss‐of‐function variant of this ge...

Induction of transferrin receptor 1-mediated ferroptosis by ultrasound-triggered microbubble destruction sensitizes glioblastoma to radiotherapy

Abstract Ultrasound-triggered microbubble destruction (UTMD), a non-invasive technique, has been proposed as a promising means of improving the efficacy of radiotherapy against glioblastoma (GBM); however, the underlying mechanisms remain to be fully clarified. Here, UTMD was sho...

Biohybrid M13 phage backpacks for active blood–brain barrier traversal and precision central nervous system leukemia treatment

Abstract Central nervous system (CNS) leukemia remains a major clinical challenge in acute lymphoblastic leukemia, largely due to the restrictive nature of the blood–brain barrier (BBB), which severely limits therapeutic delivery and contributes to high relapse rates and poor pro...

Intranasal dexmedetomidine on the effect of postoperative sleep quality for patients undergoing on-pump cardiac surgery: a prospective double-blinded randomized control study protocol

Sleep disturbances are highly prevalent in the perioperative period and are associated with poor recovery outcomes. This is particularly relevant for cardiac surgery patients, among whom sleep architecture disorders are common postoperative complications. Dexmedetomidine, a selec...

Potential roles of short-chain fatty acids in chronic obstructive pulmonary disease from the gut-lung axis perspective: an exploratory trend summary and discussion on biological mechanisms based on current evidence

Short-chain fatty acids (SCFAs) have been proposed as mediators of the gut-lung axis in chronic obstructive pulmonary disease (COPD). However, the human evidence is limited and heterogeneous across disease states and specimen types. We therefore synthesized the available evidence...

Structural and functional insights into QueC-family protein in QatABCD anti-phage system

Abstract QatABCD is a widespread prokaryotic anti-phage defense system comprising four protein components, out of which QatC, a QueC-family protein is the signature component. QueC family proteins are nucleoside biosynthesis enzymes involved in the biosynthesis of queuosine, a 7-...

Familial aggregation of cardiometabolic traits and long-term cardiometabolic risk in offspring: a 15-year prospective analysis from the PREVEND cohort

Family history is a well-established predictor of cardiometabolic risk; however, the independent prognostic contribution of sibling disease history, beyond parental history, remains to be elucidated. Using data from the prospective population-based Prevention of Renal and Vascula...

PIGU expression is associated with poor prognosis and estimated immune cell infiltration in breast invasive carcinoma

Breast invasive carcinoma (BRCA) is a major cause of cancer-related mortality in women. PIGU , a subunit of the GPI-anchor biosynthesis complex, has been reported to be dysregulated in several cancers; however, its prognostic value and immune-related associations in BRCA remain u...

Rapamycin‐nanoliposomes target the mTORC1 ‐mediated autophagy–lysosomal and NLRP3 /Caspase‐1 pathways to inhibit nucleus pulposus cell senescence in intervertebral discs

Abstract Nucleus pulposus (NP) cell quiescence maintains intervertebral disc homeostasis, while mTORC1 regulates autophagy–lysosomal function and inflammatory secretion to preserve quiescence—rapamycin specifically targets mTORC1. Herein, we fabricated rapamycin‐nanoliposomes (ra...

The Multi-Layered Effect of Panaxatriol Saponins in Preventing Diabetic Nephropathy in Mice

Background: Diabetic nephropathy (DN) is a common microvascular complication of diabetes and the leading cause of end-stage renal disease (ESRD). Nearly 40% of people with diabetes will develop DN, and DN accounts for 23% of ESRD cases in China. Dysfunction of the gut-kidney axis...