Xingtai People's Hospital

Early dynamic physiological phenotypes and bidirectional temporal associations between muscle attrition and functional decline in advanced hcc undergoing systemic therapy: a landmark analysis

Abstract Background Early treatment-related physiological changes are increasingly recognized as prognostic indicators in advanced hepatocellular carcinoma (HCC), yet they are rarely integrated into routine response assessments. This study aimed to characterize early dynamic phys...

Effectiveness and Safety of Fixed‐Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real‐World Study From China

BACKGROUND: This study assessed the real-world effectiveness and safety of a fixed-dose combination (FDC) of metformin and empagliflozin in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective, multicenter, real-world study enrolled consecutive patient...

PediatricLiver score: a novel risk score for screening elevated liver stiffness in the pediatric population (CHESS2401)

Given the looming crisis of rapid increase in childhood obesity globally, chronic metabolic diseases have consequently emerged but without sufficient awareness among children. Reliable and accessible screening tools thus are required to screen for significant liver fibrosis in th...

Association between thyroid function profiles and malnutrition severity in elderly patients

Aim To explore the of triiodothyronine (rT3) in the prognostic model of malnutrition in the elderly. Methods A total of 166 elderly patients with malnutrition were included in the experimental group, and 98 healthy people were collected as the control group. The six thyroid funct...

MiR-107 serves as a clinical biomarker for acute pancreatitis and promotes inflammation and fibrosis

Abstract Background Acute pancreatitis (AP) has a high risk of poor prognosis, yet effective biomarkers for diagnosis and prognosis remain limited. Pancreatic stellate cells (PSCs) play a central role in pancreatic inflammation and fibrosis. Purpose To investigate the diagnostic...

The relationship between serum E2F1 and MMP-9 levels and clinical and pathological characteristics and prognosis in patients with epithelial ovarian cancer

To investigate the association between serum levels of E2F transcription factor 1 (E2F1) and matrix metalloproteinase 9 (MMP-9) in patients with epithelial ovarian cancer (EOC) and their clinical and pathological characteristics and prognosis, with the aim of identifying potentia...

MiR-323b-5p regulates the development of childhood asthma by targeting the RNF24 gene

Childhood asthma is a chronic respiratory disease characterized by airway hyperresponsiveness and chronic inflammation, which involves immune dysregulation and may be associated with microRNA (miRNA) dysregulation. Exploring the clinical significance of miR-323b-5p in childhood a...

Efficacy and Safety of the First Adalimumab Biosimilar in Chinese Children with Severe Plaque Psoriasis: The PISCES Study, a Multicenter Prospective Study

Adalimumab, a monoclonal antibody targeting tumor necrosis factor-alpha, has been approved for the treatment of severe plaque psoriasis in children aged 4 years and older. Data on its use in the clinical management of pediatric psoriasis in China remains limited. This study is th...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Association between the number of missing/replaced teeth and Chronic Kidney Disease (CKD): cross-sectional analysis of NHANES data

This study aimed to investigate the association between the number of missing/replaced teeth and chronic kidney disease (CKD), and whether there is a dose-response relationship with markers of renal function. Utilizing data from the National Health and Nutrition Examination Surve...

Clinical efficacy of unilateral biportal endoscopic spinal decompression for lumbar intraspinal pneumatosis

<title>Abstract</title> Study design: Retrospective observational study. Objective To analyze the short-term clinical efficacy of unilateral biportal endoscopic (UBE) spinal decompression in the treatment of lumbar intraspinal pneumatosis. Background Lumbar intraspinal pneumatosi...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Characteristics of intrauterine microecology and Lactobacillus-associated immune profiles in patients with chronic endometritis

Chronic endometritis (CE) is a persistent inflammatory condition of the endometrium implicated in infertility and recurrent implantation failure. Microbial dysbiosis and altered immune responses are increasingly recognized as central features of its pathogenesis. This study aimed...

Prognostic value of the inflammatory prognostic index for postoperative recurrence in non-muscle-invasive bladder cancer

Abstract Background To evaluate the prognostic value of the inflammatory prognostic index (IPI) for recurrence after transurethral resection of bladder tumour (TURBT) in non-muscle-invasive bladder cancer (NMIBC), and to compare its discriminatory performance with that of the neu...

Evaluation of the efficacy and safety of different cycles of neoadjuvant chemotherapy combined with immunotherapy in locally advanced esophageal squamous cell carcinoma: a multi-center, real-world study

Neoadjuvant chemotherapy combined with immunotherapy (nCIT) can improve radiologic and pathological responses in resectable, locally advanced esophageal squamous cell carcinoma (ESCC), yet the optimal number of preoperative cycles is unknown. We conducted a multicenter, real-worl...