Xi'an Medical University

Gold Nanoparticle-Enabled Cancer Therapy: Translational Design Rules for Photothermal–Immunotherapy and Multimodal Precision Oncology

Gold nanoparticles (AuNPs) are versatile cancer-therapy platforms with tunable plasmonic properties, high atomic number, accessible surface chemistry, and potential for integration into theranostic systems. By controlling size, morphology, surface composition, and cargo-loading s...

Advantage of cerebellar intermittent theta-burst stimulation in Alzheimer's disease (ACT-AD): study protocol for a multicenter, randomized, double-blind, sham-controlled trial

Abstract Introduction The cerebellum plays a crucial role in cognitive processing and thus presents a promising therapeutic target for Alzheimer’s disease (AD). This trial aims to evaluate the efficacy and safety of long-term, neuronavigated cerebellar intermittent theta burst st...

Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism

Abstract As organisms age, mitochondrial metabolic activity declines, and disrupted gene expression regulation mediated by histone acetylation induces the emergence of senescent physiological phenotypes in tissues. In this study, we found that periodic exposure to red light signi...

Association of dietary antioxidant patterns with heart failure risk in patients with hypertension

Hypertension is a major modifiable risk factor for heart failure (HF) and contributes substantially to the cardiovascular disease burden in China. Oxidative stress and redox imbalance have been implicated in the progression from hypertension to HF. The composite dietary antioxida...

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

ABSTRACT Traumatic brain injury (TBI) induces brain tissue ischemia, hypoxia, and heightened glycolysis, leading to lactate accumulation. Lactate exerts multiple pathophysiological effects in the aftermath of TBI. This study aimed to elucidate the role of lactate‐mediated lactyla...

Peripheral blood tumor aberrantly glycosylated proteins are associated with disease progression in lung cancer

This study investigated tumor aberrantly glycosylated proteins (TAGPs) as a novel serum biomarker for lung cancer. By analyzing their associations with clinicopathological features and conventional markers, we evaluated the diagnostic efficacy of TAGPs in discriminating lung canc...

MST1 inhibition mitigates fat deposition in rotator cuff tears by modulating the WNT/β-catenin pathway

PURPOSE: Fatty infiltration of the supraspinatus muscle following rotator cuff tear (RCT) is a major pathological factor leading to poor functional outcomes, yet effective treatments are lacking. The kinase mammalian Sterile 20-like kinase 1 (MST1) has been implicated in metaboli...

Association of lipid-frailty composite indices with cardiovascular disease risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3: evidence from the UK Biobank and CHARLS

Non-traditional lipid indices have been increasingly investigated as predictors of cardiovascular disease (CVD) risk, and frailty reflects cumulative physiological decline. Whether integrating these complementary dimensions improves CVD risk prediction remains unexplored. We aime...

A semi-supervised deep learning framework (TBMNet) for automatic tumor budding quantification: real-world validation and clinical utility in stage II colorectal cancer

Abstract Background Tumor budding (TB) is a clinically important prognostic marker in colorectal cancer (CRC), but its assessment remains subjective and its biological basis is incompletely understood. We developed an artificial intelligence (AI)-based TB evaluation framework and...

Sequential Regulation of Neurovascular Bone Regeneration in Large Bone Defects Using Black Phosphorus‐Europium Nanosheet Integrated TPMS Biomimetic Scaffold with Photo‐Controlled Ion Release

ABSTRACT Titanium alloy scaffolds (Ti–6Al–4 V) are widely used to repair bone defects. However, conventional titanium‐based implants lack customized functional surface interfaces that promote coordinated local nerve and blood vessel regeneration, thereby limiting bone regeneratio...

Dentoalveolar surgery education in Chinese undergraduate dental schools: a national survey of curriculum structure, simulation training and assessment

Dentoalveolar surgery is a core component of undergraduate dental education; however, evidence regarding its implementation in Chinese dental schools remains limited. This study investigated curriculum structure, teaching methods, simulation training, and assessment strategies fo...

Navigating the diagnostic pitfall of concealed brachial artery disconnection masquerading as simple elbow dislocation

Abstract Background Although neurovascular injuries are known complications of elbow dislocations, they typically present with obvious signs of ischemia. However, it is extremely rare for a complete arterial disconnection to masquerade as a simple dislocation. This specific type...

Combined Hyaluronic Acid and Collagen Injections for Perioral Rejuvenation: A Randomized Controlled Trial

ABSTRACT Background The perioral region, a critical facial aesthetic subunit, undergoes age‐related changes addressed primarily through dermal fillers. Optimal rejuvenation requires tailored approaches integrating anatomical precision, filler physicochemical properties, and stand...

Traditional Chinese Herbal Formula YA3D3 Ameliorates Alzheimer's Disease-Like Pathology and Cognitive Impairment in APP/PS1 Transgenic Mice.

therapeutic efficacy of YA3D3 and the up-regulation of ATG14 requires further confirmation.In addition，this study only verifies the expression regulation of autophagy-related molecules and does not confirm the enhancement of autophagy flux.

Machine learning-based prediction model for 2-year tooth loss risk in periodontitis patients: integrating radiographic features and clinical parameters

To develop and internally–externally validate a multidomain machine-learning (ML) model for 2-year tooth loss in periodontitis patients using exclusively baseline predictors, and to quantify the incremental value of radiographic over clinical features. This multicenter retrospect...

The effect of social support on physical activity of hemodialysis patients : the chain mediating role of exercise self-efficacy and barriers to exercise benefits

Abstract Background Maintenance hemodialysis patients exhibit low physical activity, which is associated with sarcopenia, increased risk of cardiovascular events, and elevated all-cause mortality. Social support is an important resource for promoting healthy behaviors. But the me...

Orthopedic Biomaterials in the Clinical Reconstruction of Osteoporotic Atlantoaxial Injuries: A Review

Background: Aging of the population increases the incidence of osteoporosis with atlantoaxial instability. Poor bone microarchitecture causes high rates of screw loosening, implant failure, and revision surgery, which remains a critical challenge for upper cervical surgery. Tradi...

An ioversol-enhanced micro-CT workflow for hematoma visualization and preoperative localization in a murine autologous blood model of intracerebral hemorrhage

Abstract Autologous blood injection produces a discrete striatal clot in mice, but the hematoma is usually confirmed only after brain removal and sectioning, making craniotomy planning difficult for evacuation studies. To address this limitation, we mixed freshly collected autolo...

Lysosome‐Targeted Self‐Adjuvanting Ammonia Nanogenerator Potentiates Hepatocellular Carcinoma Immunotherapy via Ammonia Death

ABSTRACT Ammonia death is a recently identified form of regulated cell death with unique molecular mechanisms and prominent anticancer activity. Nevertheless, its efficacy is severely restricted by the absence of tumor‐targeted ammonia delivery vehicles and poorly defined immunog...

The bidirectional Thymus-Gut Axis: redefining central tolerance in digestive autoimmunity

Digestive autoimmune diseases impose an escalating global burden, largely because current therapies predominantly target downstream inflammation rather than primordial defects in immune tolerance. The thymus establishes central tolerance through stringent T cell selection and thy...