Xi'an Honghui Hospital

Single-cell RNA sequencing reveals chondrocyte heterogeneity and fibrocartilage transition in osteonecrosis of the femoral head

Cartilage degeneration in osteonecrosis of the femoral head (ONFH) is closely associated with chondrocyte heterogeneity. Single-cell RNA sequencing was performed on 50,851 chondrocytes from 10 ONFH patients and 10 controls. The findings were further validated using an in vitro ch...

Orthopedic Biomaterials in the Clinical Reconstruction of Osteoporotic Atlantoaxial Injuries: A Review

Background: Aging of the population increases the incidence of osteoporosis with atlantoaxial instability. Poor bone microarchitecture causes high rates of screw loosening, implant failure, and revision surgery, which remains a critical challenge for upper cervical surgery. Tradi...

Determining the minimal clinically important difference for EQ-5D-5L scores in patients undergoing primary total knee arthroplasty

Total Knee Arthroplasty (TKA) is a common procedure for knee osteoarthritis, but the Minimal Clinically Important Difference (MCID) for the EQ-5D-5L scale in TKA patients is not established. This study aims to determine the MCID for EQ-5D-5L in TKA patients. A prospective study w...

Nonlinear association between maternal depressive symptoms and overreactive parenting among preschool children: a cross-sectional study

Maternal depressive symptoms (MDS) have been associated with negative parenting practices. However, research examining the specific pattern between MDS and overreactive parenting remains limited. Our objective was to comprehensively assess the association between MDS and overreac...