Institution
Xi'an Honghui Hospital
Recent research
- Health & MedicineOpen access
Abstract Knee osteoarthritis (KOA) is increasingly recognized as a whole-joint mechano-inflammatory disorder in which abnormal loading, tissue remodeling, and inflammatory sensitization reinforce one another. Piezo1 is a context-dependent mechanotransduction hub that links mechan...
- BiologyOpen access
MACF1 condensates serve as molecular rheostats translating mechanical stress into bone adaptation
Bone dynamically maintains homeostasis through mechanotransduction, a process essential for skeletal integrity and frequently disrupted in disease. Yet how bone cells decode mechanical cues into adaptive responses remains poorly understood. Here, we identify MACF1, a cytoskeletal...
- Health & MedicineOpen access
Age-Associated Differences in Facial Skin Structure in Chinese Women: a Cross-Sectional Study
Facial skin aging is a process leading to structural degradation and visible phenotypical changes. Prior studies examined age-related skin parameters and suggested accelerated changes occurring in the early 30s, yet precise timing remains insufficiently defined, and few assessed...
- Health & Medicine
Purpose: This single-phantom CT-referenced technical-validation study evaluated residual length and angular measurement bias after source-to-image distance/source-to-object distance (SID/SOD) calibration in full-length lower-limb radiography using system/protocol configurations r...
- Engineering & TechnologyOpen access
Self-regulated immune-neurovascular bone repair scaffold via functional surface features
Given specific microenvironment of bone repair, the novel implant endowed with self-regulated bone healing procedure was the representative trend of bio-functional decoration. Inspired by the microstructure and chemical composition of natural bone, bioactive calcium titanate coat...
- Biology
ABSTRACT Postmenopausal osteoporosis (PMOP) is frequently complicated by iron accumulation, which exacerbates bone loss. Baicalein, a natural flavonoid with iron‐chelating and antioxidant properties, has shown bone‐protective effects, but its role in iron‐overloaded PMOP remains...
- Engineering & TechnologyOpen access
The fibrin network formed during the early bone repair establishes a viscoelastic micromechanical niche that recruits cells and releases cytokines, playing a pivotal role in primary callus formation. However, conventional metallic implants often lack these dynamic, bioactive cues...
- Engineering & TechnologyOpen access
From mechanical repair to biological regeneration: a review on β-TCP for bone repair
The innovative synthesis and performance enhancement of bone tissue repair materials are pivotal in advancing orthopedic surgery. β-tricalcium phosphate (β-TCP), renowned for its excellent biocompatibility, biodegradability, and mechanical properties matching those of bone tissue...
- Engineering & TechnologyOpen access
Tumor heterogeneity and an immunosuppressive microenvironment are major obstacles to effective cancer immunotherapy. Personalized nanovaccines derived from autologous tumor cells offer a compelling strategy to overcome these challenges by preserving the full spectrum of patient-s...
- Health & MedicineOpen access
Mitochondria-targeted therapy: a promising treatment strategy for intervertebral disc degeneration
Low back pain (LBP) is a prevalent musculoskeletal disorder worldwide, and intervertebral disc degeneration (IDD) constitutes its primary etiological factor. With the continuous advancement of research, an increasing number of studies have demonstrated that mitochondrial dysfunct...
- BiologyOpen access
Zygosaccharomyces rouxii is a halotolerant yeast widely associated with traditional high-salt food fermentations, while also being recognized as a spoilage microorganism in some food systems. Although its performance in fermented foods is strongly influenced by high salinity, the...
- Health & Medicine
ABSTRACT Gastric polyps are clinically important lesions whose accurate delineation in endoscopic images can support lesion assessment and treatment planning. However, small size, weak contrast, irregular morphology, indistinct boundaries, and interference from surrounding gastri...
- Health & MedicineOpen access
Cartilage degeneration in osteonecrosis of the femoral head (ONFH) is closely associated with chondrocyte heterogeneity. Single-cell RNA sequencing was performed on 50,851 chondrocytes from 10 ONFH patients and 10 controls. The findings were further validated using an in vitro ch...
- Health & MedicineOpen access
Background: Aging of the population increases the incidence of osteoporosis with atlantoaxial instability. Poor bone microarchitecture causes high rates of screw loosening, implant failure, and revision surgery, which remains a critical challenge for upper cervical surgery. Tradi...
- Health & MedicineOpen access
Total Knee Arthroplasty (TKA) is a common procedure for knee osteoarthritis, but the Minimal Clinically Important Difference (MCID) for the EQ-5D-5L scale in TKA patients is not established. This study aims to determine the MCID for EQ-5D-5L in TKA patients. A prospective study w...
- Society & EconomicsOpen access
Maternal depressive symptoms (MDS) have been associated with negative parenting practices. However, research examining the specific pattern between MDS and overreactive parenting remains limited. Our objective was to comprehensively assess the association between MDS and overreac...