Xian Central Hospital

Skeletal Muscle DPT Ameliorates Obesity and Metabolic Dysfunction via the PERK/eIF2α/ATF4-GDF15 Axis

Skeletal muscle plays a pivotal role in maintaining metabolic homeostasis by acting as a primary site for glucose disposal and insulin-mediated energy use. Here, through RNA sequencing of skeletal muscle from individuals with normal weight versus obesity, we identified that the e...

Prognostic impact of adjuvant chemoradiotherapy and genes methylation on localized urothelial carcinoma patients

In the management of muscle-invasive urothelial carcinoma, radiotherapy serves as an important adjuvant treatment to radical cystectomy. Evidence from other cancers indicates that synchronous chemoradiotherapy is associated with enhanced local control and survival outcomes when c...

Effectiveness and Safety of Fixed‐Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real‐World Study From China

BACKGROUND: This study assessed the real-world effectiveness and safety of a fixed-dose combination (FDC) of metformin and empagliflozin in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective, multicenter, real-world study enrolled consecutive patient...

Mammalian DNA maintenance methylation depends on histone but not PAF15 ubiquitination

In mammals, DNA methylation is an essential inheritable epigenetic modification maintained by the DNMT1-UHRF1 machinery in a UHRF1 E3 ubiquitin ligase-activity-dependent manner. UHRF1-catalyzed histone ubiquitination and PAF15 ubiquitination have been proposed to recruit DNMT1 to...

The relationship between serum E2F1 and MMP-9 levels and clinical and pathological characteristics and prognosis in patients with epithelial ovarian cancer

To investigate the association between serum levels of E2F transcription factor 1 (E2F1) and matrix metalloproteinase 9 (MMP-9) in patients with epithelial ovarian cancer (EOC) and their clinical and pathological characteristics and prognosis, with the aim of identifying potentia...

Mechanical properties and damage evolution mechanism of rubber-gangue cemented backfill under different loading rates

Abstract This study investigates the rate-dependent mechanical behavior and damage evolution of rubber-modified cemented gangue backfill through multi-scale macroscopic and microscopic tests. A piecewise statistical damage constitutive model based on the Weibull distribution is e...

SOHLH2 downregulation marks CD163-positive M2-like immunoregulatory marrow remodeling in acute myeloid leukemia: a single-center retrospective cohort study

The immunosuppressive marrow niche is a driver of acute myeloid leukemia (AML) persistence, yet transcriptional signals linked to macrophage skewing remain poorly defined. SOHLH2, a tumor-suppressive transcription factor in solid cancers, has not been characterized in AML. We inv...

Ki-67/p53-associated angiogenic heterogeneity for preoperative WHO grading of meningiomas: a spatial habitat radiomics study

This study aimed to develop and validate a classification model for preoperative prediction of WHO grading of meningioma based on spatial habitat radiomics that can be explained by Ki-67 and p53 biomarkers. A retrospective cohort of 400 patients (261 WHO grade I; 139 grade II/III...