Xian Central Hospital

SOHLH2 downregulation marks CD163-positive M2-like immunoregulatory marrow remodeling in acute myeloid leukemia: a single-center retrospective cohort study

The immunosuppressive marrow niche is a driver of acute myeloid leukemia (AML) persistence, yet transcriptional signals linked to macrophage skewing remain poorly defined. SOHLH2, a tumor-suppressive transcription factor in solid cancers, has not been characterized in AML. We inv...

Ki-67/p53-associated angiogenic heterogeneity for preoperative WHO grading of meningiomas: a spatial habitat radiomics study

This study aimed to develop and validate a classification model for preoperative prediction of WHO grading of meningioma based on spatial habitat radiomics that can be explained by Ki-67 and p53 biomarkers. A retrospective cohort of 400 patients (261 WHO grade I; 139 grade II/III...