Xiamen Chang Gung Hospital

ATF4 and FGFR4 cooperatively support thyroid cancer progression and CAF-associated tumor-promoting features

Aggressive thyroid cancer remains difficult to treat, partly because molecular programs linking malignant behavior to cancer-associated fibroblast (CAF)-related support are incompletely defined. This study investigated whether ATF4 and FGFR4 cooperate in thyroid cancer cells and...

Development and internal validation of a nomogram for predicting endometrial polyp recurrence after hysteroscopic polypectomy

Endometrial polyps (EP) are common, and hysteroscopic polypectomy is the reference treatment, but recurrence is frequent. This study aimed to identify risk factors for recurrence and to develop and internally validate a nomogram for individual postoperative risk stratification. I...

Abdominal Acupuncture in Improving Allergic Rhinitis Through Estrogen Inhibition and Regulation of Immune Factor Secretion

Abstract Background Allergic rhinitis (AR) is a common allergic disease with limited treatment options and potential side effects from conventional therapies. This study aimed to investigate the therapeutic effects and underlying mechanisms of abdominal acupuncture (AA) on AR. Me...

Integrated Metabolomic and Metagenomic Profiling Reveals Distinct Microbial–Metabolic Signatures in the Adenoma–Carcinoma Sequence of Colorectal Cancer

Colorectal cancer (CRC) arises via the stepwise adenoma-carcinoma sequence (ACS). Gut microbial dysbiosis and host metabolic reprogramming jointly correlate with CRC onset and advancement, yet their stage-specific crosstalk across ACS remains largely unclear. Limited multi-omics...