Xiamen Chang Gung Hospital

Organelle contact sites as intracellular communication hubs linking metabolic stress to inflammatory disease

Abstract Membrane contact sites (MCSs) are specialized, non-fusogenic interfaces that allow organelles to exchange ions, lipids, metabolites and stress signals. These contacts support adaptation to nutrient, proteotoxic and inflammatory stress. However, persistent or misregulated...

Evaluation of a new non-competitive chemiluminescent immunoassay for 25-OH vitamin D measurement

Abstract Objectives The increasing demand for vitamin D measurement over the past few decades has prompted manufacturers to develop automated chemiluminescence immunoassay (CLIA), including the noncompetitive anti-immune complex assay (NACA) system for the measurement of small mo...

Remnant cholesterol inflammatory index and new-onset Fried-phenotype frailty in middle-aged and older Chinese adults: a prospective CHARLS cohort study

Abstract Background Composite indices combining remnant cholesterol with high-sensitivity C-reactive protein (hs-CRP) may capture frailty-relevant inflammatory–lipid risk. The remnant cholesterol inflammatory index (RCII) has been linked to cardiometabolic disease and Frailty-Ind...

miR-892b targeting CTNNB1 regulates sepsis-induced myocardial dysfunction

Numerous sepsis patients experience myocardial damage, leading to a high mortality rate of sepsis. To investigate the clinical and functional role of miR-892b in sepsis-induced myocardial dysfunction (SMD). The expression of miR-892b and CTNNB1 in clinical subjects was measured b...

Efficacy and Safety of Recibokibart, an Interleukin-36 Receptor Antibody, in Generalized Pustular Psoriasis: A Phase 2 Randomized Trial

BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by acute flares. Recibokibart is a humanized IgG1 monoclonal antibody targeting the interleukin-36 (IL-36) receptor. In a phase 1b open-label study, a single intravenous dos...

Subdivision of metachronous metastatic nasopharyngeal carcinoma based on the framework of TNM-9: A recursive partitioning analysis of real-world data

Abstract Purpose: To validate the prognostic value of the M1 category in version nine of the AJCC/UICC TNM staging system (TNM-9) in metachronous metastatic nasopharyngeal carcinoma (mmNPC) and to develop a refined M1 classification for improved risk stratification. Methods: Pati...

ATF4 and FGFR4 cooperatively support thyroid cancer progression and CAF-associated tumor-promoting features

Aggressive thyroid cancer remains difficult to treat, partly because molecular programs linking malignant behavior to cancer-associated fibroblast (CAF)-related support are incompletely defined. This study investigated whether ATF4 and FGFR4 cooperate in thyroid cancer cells and...

Development and internal validation of a nomogram for predicting endometrial polyp recurrence after hysteroscopic polypectomy

Endometrial polyps (EP) are common, and hysteroscopic polypectomy is the reference treatment, but recurrence is frequent. This study aimed to identify risk factors for recurrence and to develop and internally validate a nomogram for individual postoperative risk stratification. I...

Abdominal Acupuncture in Improving Allergic Rhinitis Through Estrogen Inhibition and Regulation of Immune Factor Secretion

Abstract Background Allergic rhinitis (AR) is a common allergic disease with limited treatment options and potential side effects from conventional therapies. This study aimed to investigate the therapeutic effects and underlying mechanisms of abdominal acupuncture (AA) on AR. Me...

Integrated Metabolomic and Metagenomic Profiling Reveals Distinct Microbial–Metabolic Signatures in the Adenoma–Carcinoma Sequence of Colorectal Cancer

Colorectal cancer (CRC) arises via the stepwise adenoma-carcinoma sequence (ACS). Gut microbial dysbiosis and host metabolic reprogramming jointly correlate with CRC onset and advancement, yet their stage-specific crosstalk across ACS remains largely unclear. Limited multi-omics...