Wythenshawe Hospital

Standards for practical management of drug hypersensitivity reactions to intravenous drugs and proactive early allergy involvement before referral: A WAO Statement

Hypersensitivity reactions to intravenous therapies—including antibiotics, chemotherapeutics, biologics, anesthesia agents, and contrast media—pose significant challenges in acute care settings. These reactions often occur outside the purview of allergy specialists, leading to de...

Economic and health impact of integrating smoking cessation services into NHS cancer care pathways in England: a modelling study

Background Research has shown that smoking post-diagnosis negatively impacts cancer outcomes. This study aimed to assess the health and cost impacts of introducing smoking cessation services at cancer diagnosis for people who smoke. Methods A cost-effectiveness model was develope...

The Role of Neurofilaments in Diagnosis and Monitoring of Amyotrophic Lateral Sclerosis

Background: Amyotrophic lateral sclerosis (ALS), the most common type of motor neurone disease (MND), is a devastating diagnosis that often leads to mortality within 2–5 years of symptom onset. Respiratory failure and aspiration pneumonia both associated with respiratory muscle w...

EUS-guided and US-guided percutaneous splenic biopsy: a systematic review and meta-analysis of separately pooled diagnostic and safety outcomes

Ultrasound (US)-guided percutaneous splenic biopsy has been widely used to evaluate focal or diffuse splenic lesions and has shown promising efficacy and safety. Endoscopic ultrasound (EUS)-guided biopsy has emerged as an alternative approach for tissue acquisition from splenic l...