Wuxi No.2 People's Hospital

Targeting REV7 confers cervical cancer cell radiosensitivity and ferroptosis by negatively regulating SFXN1

Cervical cancer is the 4th most common malignancy in women. Radiotherapy (RT) plays an essential role in cervical cancer treatments, and this study reports the role of REV7 in cervical cancer RT. Results showed that loss of REV7 contributed to increased the radiosensitivity of ce...

Nanozymes in Upper Respiratory Tract Infections: Catalytic Mechanisms, Current Evidence, and Emerging Theranostic Strategies

Abstract Objective: This review evaluates nanozymes as catalytic biomaterials for upper respiratory tract infection (URTI)-related diagnosis, therapy, and prevention, with particular attention to differences in the maturity of evidence across these applications. The anatomically...

WTAP-induced upregulation of KDR ameliorates angiotensin II-induced apoptosis, oxidative stress and ferroptosis of human brain microvascular endothelial cells

Abstract Background Intracranial aneurysms (IAs) are a significant cause of morbidity and mortality, often leading to subarachnoid hemorrhage and subsequent neurological deficits. The kinase insert domain receptor (KDR) plays a crucial role in vascular cell function during IA. Ho...

Association between age and outcomes of evidence-based feeding protocol versus usual care in critically ill patients: secondary analysis of a multicenter cluster-randomised controlled trial

BACKGROUND: Nutrition therapy is essential in critically ill patients, yet large randomised trials have shown inconsistent results regarding the effect of an evidence-based feeding protocol. The NEED trial showed a feeding protocol could effectively promote delivery of enteral nu...

Combined effect of heart disease and high CRP levels on new-onset stroke in middle-aged and older Chinese adults: a prospective cohort study from CHARLS

Abstract Background This study aimed to investigate whether the coexistence of heart disease and high C-reactive protein (CRP) levels increases the risk of new-onset stroke among middle-aged and elderly Chinese individuals. Methods The analysis incluCombined Effect of Heart Disea...

Carnosol Accelerates Pressure Ulcer Healing via Keap1-Nrf2/HO-1-Mediated Mitochondrial Quality Control

Abstract Pressure ulcer pathogenesis involves ischemia-reperfusion-induced oxidative stress and mitochondrial dysfunction. Carnosol, a rosemary-derived diterpene with antioxidant properties, was investigated for its therapeutic potential in tissue repair. Carnosol pretreatment pr...

Enhancing swin transformer via ProbAttention and Convolutional Block Attention Module for traffic sign recognition

In autonomous driving systems, traffic sign recognition (TSR) serves as a pivotal component for safeguarding driving safety and boosting operational efficiency. Conventional approaches to TSR, which depend on manual visual assessment, suffer from high labor intensity, excessive t...

Clinical and neurophysiology study of 17 children with epileptic negative myoclonus

BACKGROUND: Epileptic negative myoclonus (ENM) is a clinically underrecognized seizure type, and systematic data on its clinical manifestations and optimal management strategies in pediatric populations remain scarce. This case series aimed to describe the clinical manifestations...

Effect of SEEKflex-guided versus conventional intubation on hemodynamic responses in elderly hypertensive patients: a randomized controlled trial

In elderly patients with preexisting cardiovascular and cerebrovascular diseases, laryngoscopy and tracheal intubation can provoke substantial hemodynamic disturbances, including hypertension and tachycardia, which may precipitate major cardiovascular or cerebrovascular events an...