Wuxi Fourth People's Hospital

Clinical and neurophysiology study of 17 children with epileptic negative myoclonus

BACKGROUND: Epileptic negative myoclonus (ENM) is a clinically underrecognized seizure type, and systematic data on its clinical manifestations and optimal management strategies in pediatric populations remain scarce. This case series aimed to describe the clinical manifestations...

Gut microbiota-derived indoleacrylic acid ameliorates rheumatoid arthritis by preventing necroptosis of fibroblast-like synoviocytes and regulating macrophage polarization

Rheumatoid arthritis (RA) is associated with gut metabolite dysfunction, but the contribution of tryptophan-derived metabolites to RA remains fully uncharacterized. Here, we investigated the role of the gut microbiota-derived tryptophan metabolite indoleacrylic acid (IA) in exper...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Extraction-reasoning gaps in open-source LLM grading of liver pathology reports

Large language models (LLMs) may reduce the manual effort required to convert narrative pathology reports into structured research data, but it remains unclear whether their performance reflects extraction of explicit diagnostic labels or genuine histopathological reasoning. We e...

Deep N-glycoproteomic profiling of FFPE tissues enables precise diagnosis of primary liver cancer from metastatic liver cancer

Reliable tumor origin assessment from routinely archived specimens remains challenging, particularly for diagnostically ambiguous liver malignancies. Although formalin-fixed, paraffin-embedded (FFPE) tissues are widely available, deep and quantitative site-specific N-glycoproteom...

From microbial dysbiosis to putative epigenetic locking: a hypothesis-driven framework for the pathogenesis and future therapeutic perspectives of gastric intestinal metaplasia

Intestinal metaplasia (IM) is a key precancerous lesion connecting chronic atrophic gastritis and gastric cancer in the Correa cascade, and its risk of progression has significant individual heterogeneity. A potential explanatory framework for this heterogeneity involves interact...