Wuxi Fourth People's Hospital

Symptom clusters and help-seeking behaviours during neutropenia after autologous haematopoietic stem cell transplantation: A qualitative study to inform oncology nursing support

Purpose To explore how adult autologous haematopoietic stem cell transplantation recipients experience and appraise symptom constellations during neutropenia, and how these appraisals shape help-seeking and interactions with clinicians. Methods A qualitative descriptive study was...

Nanozymes in Upper Respiratory Tract Infections: Catalytic Mechanisms, Current Evidence, and Emerging Theranostic Strategies

Abstract Objective: This review evaluates nanozymes as catalytic biomaterials for upper respiratory tract infection (URTI)-related diagnosis, therapy, and prevention, with particular attention to differences in the maturity of evidence across these applications. The anatomically...

ECT2 antagonizes lipoic acid to modulate papillary thyroid carcinoma progression through energy metabolism pathways

ECT2 exhibits context-dependent oncogenic or tumor-suppressive roles across multiple cancer types, with its functional output determined by cell-intrinsic factors and extrinsic microenvironmental cues. Nevertheless, the expression dynamics, clinical relevance, and mechanistic und...

Targeted agents combined with immune checkpoint inhibitors in advanced non-small cell lung cancer: a systematic review and externally anchored Bayesian network meta-analysis

Targeted agents combined with PD-1 or PD-L1 blockade have been investigated in advanced non-small cell lung cancer (NSCLC), but the evidence is dominated by small single-arm studies in clinically distinct populations. We evaluated class-level activity, safety, and progression-fre...

Clinical and neurophysiology study of 17 children with epileptic negative myoclonus

BACKGROUND: Epileptic negative myoclonus (ENM) is a clinically underrecognized seizure type, and systematic data on its clinical manifestations and optimal management strategies in pediatric populations remain scarce. This case series aimed to describe the clinical manifestations...

Gut microbiota-derived indoleacrylic acid ameliorates rheumatoid arthritis by preventing necroptosis of fibroblast-like synoviocytes and regulating macrophage polarization

Rheumatoid arthritis (RA) is associated with gut metabolite dysfunction, but the contribution of tryptophan-derived metabolites to RA remains fully uncharacterized. Here, we investigated the role of the gut microbiota-derived tryptophan metabolite indoleacrylic acid (IA) in exper...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Extraction-reasoning gaps in open-source LLM grading of liver pathology reports

Large language models (LLMs) may reduce the manual effort required to convert narrative pathology reports into structured research data, but it remains unclear whether their performance reflects extraction of explicit diagnostic labels or genuine histopathological reasoning. We e...

Deep N-glycoproteomic profiling of FFPE tissues enables precise diagnosis of primary liver cancer from metastatic liver cancer

Reliable tumor origin assessment from routinely archived specimens remains challenging, particularly for diagnostically ambiguous liver malignancies. Although formalin-fixed, paraffin-embedded (FFPE) tissues are widely available, deep and quantitative site-specific N-glycoproteom...

From microbial dysbiosis to putative epigenetic locking: a hypothesis-driven framework for the pathogenesis and future therapeutic perspectives of gastric intestinal metaplasia

Intestinal metaplasia (IM) is a key precancerous lesion connecting chronic atrophic gastritis and gastric cancer in the Correa cascade, and its risk of progression has significant individual heterogeneity. A potential explanatory framework for this heterogeneity involves interact...