WuXi AppTec (China)

Small interfering RNA targeting protein Z-dependent protease inhibitor improves hemostasis in Von Willebrand factor- and Factor X-deficient mice

Non-factor therapeutics have transformed the treatment paradigm in hemophilia A. Owing to their mode of action, these agents may also provide benefit for other rare bleeding disorders (RBDs) such as von Willebrand disease (VWD)-type 3 and Factor X (FX) deficiency. Targeting prote...

Construction of Quinoline-4-carboxylic Acids via DNA-Compatible Doebner Reaction

Abstract The Doebner reaction is a classical method for the synthesis of quinoline-4-carboxylic acids via the condensation of anilines, aldehydes, and pyruvic acid. However, its application in DNA-encoded library (DEL) technology has been limited due to harsh reaction conditions...

Adaptive Sage-Husa Kalman filter for 3D indoor positioning with multi-sensor fusion

In complex indoor environments, standalone bluetooth positioning often suffers from significant performance degradation due to non-line-of-sight (NLOS) propagation and environmental disturbances. Meanwhile, position estimates derived from inertial measurement unit (IMU) data are...

Evaluation of the Anti-Neuroinflammatory Activity of Theophylline Derivatives in Activated Microglia

Abstract ctive: Microglial activation-mediated neuroinflammation is a pivotal pathological hallmark of various neurological disorders. Although theophylline suppresses pro-inflammatory cytokine secretion, and 1,2,3-triazole scaffolds possess intrinsic anti-inflammatory properties...

Reprocessable, Creep‐Resistant and Fully Biobased Thermosets for Power Semiconductor Packaging

ABSTRACT Amid rapid advances in third‐generation semiconductors and holistic life‐cycle management, thermoset‐based packaging materials are evolving toward high‐temperature resistance, eco‐friendliness, and reprocessability. However, beyond the pursuit of recyclable carbon, therm...

Development of GuaB Inhibitors to Treat Mycobacterium tuberculosis Infection

Abstract Mycobacterium tuberculosis (Mtb) is responsible for more deaths per year than any other infectious disease. Resistance of circulating Mtb to the standard of care treatment regimen is an urgent global health crisis for which novel antibiotic treatments are needed. We have...

A biodegradable piezoelectric vertebral implant for programmable electro-neuromodulation in spinal cord injury

Spinal cord stimulation has emerged as a promising therapeutic strategy for spinal cord injury (SCI), yet conventional electronic implants remain limited by surgical risk and long-term safety concerns. We introduce a biodegradable piezoelectric cryogel (Piezo Gel) that enables pr...

Low temperature selective catalytic oxidation of ammonia reaction (NH3-SCO): Introducing Co, or Zr to improve comprehensive performance of the Ag/Al2O3 catalyst.

oxidation pathway.