Wuhan Union Hospital

MD ‐1 Deficiency Mitigates Atherosclerosis by Inhibiting NLRP3 Inflammasome Activation via cGAS ‐ STING Dependent Pathway in Macrophages

ABSTRACT MD‐1 plays significant roles in various pathological processes closely associated with cardiovascular diseases through its functions in different cell types. However, the critical effects and molecular mechanisms mediated by MD‐1 in macrophages involved in the developmen...

Deubiquitinating Enzymes in Alzheimer’s Disease: From Protein Homeostasis to Diverse Pathological Processes

Alzheimer’s disease (AD) is a neurodegenerative disorder involving multiple pathological processes, including amyloid-β (Aβ) accumulation, tau pathology, impaired autophagy, mitochondrial dysfunction, neuroinflammation, and synaptic dysfunction. Deubiquitinating enzymes (DUBs) re...

Associations of Triglyceride Glucose Index-related Obesity Indices, Genetic Susceptibility, and the Risk of Venous Thromboembolism: Insights from a Prospective Cohort Study

Abstract The triglyceride glucose (TyG) index and related obesity metrics are commonly recognized as important indicators of insulin resistance. However, the associations of several novel TyG-related obesity indices developed with venous thromboembolism (VTE) risk and their inter...

Extended follow-up of in vivo BCMA CAR-T therapy in relapsed/refractory multiple myeloma

Data on long-term outcomes of in vivo chimeric antigen receptor T cell (CAR‑T) therapy remain scarce. We previously reported preliminary safety and efficacy data of in vivo B-cell maturation antigen (BCMA) CAR‑T (ESO-T01), in four patients with relapsed/refractory multiple myelom...

Associations between diabetic retinopathy and systemic complications in patients with type 2 diabetes mellitus: a retrospective cross-sectional analysis of the PHDA diabetes complications data set in China

To investigate the associations between diabetic retinopathy (DR) and selected systemic complications in patients with type 2 diabetes mellitus (T2DM). This retrospective cross-sectional study analyzed data from the National Population Health Science Data Center’s PHDA Diabetes C...

Arrayed Magnetic Accelerator Synergistically Enhances Orthodontic Tooth Movement via Microtubule Assembly‐Mediated Periodontal Remodeling

ABSTRACT Mechanical orthodontic treatment is regarded as a classical strategy for directional tooth movement in confront of malocclusion. However, prolonged remodeling period and adverse complication risks, which are mainly ascribed to inadequate sensation of bio‐mechanical cues,...

Upcoming novel treatments for hidradenitis suppurativa: An overview of the pipeline

Abstract Recent developments in hidradenitis suppurativa (HS) have focused on targeting key inflammatory pathways implicated in the pathogenesis of the disease, including interleukin (IL)‐17, IL‐1, tumour necrosis factor (TNF), Janus kinase (JAK) and tyrosine kinase 2 (TYK2) sign...

Liquid biopsy, cfDNA, and machine learning: an integrative approach to cardiovascular diseases

Cardiovascular diseases (CVDs) and their complications remain the leading cause of mortality worldwide. However, obtaining diseased cardiovascular tissue is often invasive, costly, and clinically impractical, highlighting the need for noninvasive approaches that can capture dynam...

Mapping the Evidence on Midline Catheter Tip Location, Confirmation Methods and Associated Characteristics: A Scoping Review

BACKGROUND: Midline catheters (MCs) are increasingly utilized as an alternative to peripheral and central venous catheters. However, the lack of standardized protocols for tip location and confirmation methods remains a significant barrier to patient safety and clinical decision-...

Transformer‐Based Multitask Framework Integrating Habitat and Deep Learning for Predicting Early Disease Control and Survival in Immunotherapy‐Treated Hepatocellular Carcinoma

ABSTRACT Hepatocellular carcinoma (HCC) patients show heterogeneous responses to immune checkpoint inhibitors (ICIs). This study developed ECOS‐Net, a transformer‐based multitask network integrating CT‐derived habitat and 2.5‐dimensional (2.5D) deep learning features for simultan...

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

ABSTRACT Acquired resistance to temozolomide (TMZ) remains a major therapeutic challenge in glioblastoma (GBM), with metabolic reprogramming emerging as a critical driver of treatment failure. Procollagen lysyl hydroxylase 1 (PLOD1) is identified as a key regulator of adaptive me...

An ROS‐Responsive CeO 2 –Selenium Nanozyme Mitigates Renal Injury via Coordinated Ferroptosis Inhibition and Inflammation Resolution

ABSTRACT Acute kidney injury (AKI) and chronic kidney disease (CKD), despite distinct etiologies, share a common pathological axis characterized by reactive oxygen species (ROS) burst, ferroptosis activation, and sustained inflammation. Targeting this ROS–ferroptosis–inflammation...

Payment reform, remuneration incentives, and changes in service utilization and institutional revenue composition: an interrupted time-series analysis from Sanming, China

Hospital-centred service delivery and underused primary care can reduce health-system efficiency. We examined changes in service utilization, provider distribution, and institutional revenue composition during Sanming’s health reform. We analysed 144 monthly observations from Jan...

Intrapartum ultrasound in the second-stage labor: a meta-analysis and evidence appraisal of clinical outcomes and safety

Abstract Background Accurate assessment of fetal head position and descent during the second stage of labor is essential for safe decision-making, but digital examination is subjective and operator-dependent. Intrapartum ultrasound has been proposed as an objective adjunct, yet i...

Aptamer-functionalized EGCG nanocarrier for neutrophil-targeted AKBA delivery promotes anxiety-related fracture healing

Anxiety is clinically associated with impaired fracture healing, but the underlying immunological mechanism remains unclear, and no targeted therapy is available. In a mouse model of chronic restraint stress (CRS)-induced anxiety with femoral fracture, we observed expansion of TG...

Rimegepant for vestibular and cochlear symptoms associated with vertigo in a real-world retrospective study

Vertigo commonly co-occurs with cochlear symptoms, yet evidence for calcitonin gene-related peptide (CGRP) receptor antagonists across audiovestibular disorders remains limited. We retrospectively evaluated 54 adults with vertigo who received rimegepant 75 mg daily or every other...

Sodium L-lactate alleviates DSS-induced colitis through gut microbiota remodeling and Akkermansia enrichment

L-lactate, a byproduct of glycolysis and hypoxia, accumulates in the gut during disease progression and may affect host responses and microbial metabolism. Here, we investigated the protective effect of sodium L-lactate on dextran sulfate sodium (DSS)-induced colitis in mice and...

Risk factors for postoperative hypoxemia in Stanford type A aortic dissection: a cohort study from the Hubei Aortic Dissection Registration Database

Abstract Background For patients with Stanford type A aortic dissection (STAAD), moderate-to-severe hypoxemia is a common and serious complication after surgery. However, its independent risk factors are not yet well understood, and there is a lack of effective early prediction t...

Recent advances in anticoagulant-related nephropathy: risk factors, peribiopsy and therapeutic anticoagulation

Abstract The concept of anticoagulant-related nephropathy (ARN), first proposed in 2009, manifests as acute kidney injury or the rapid deterioration of chronic kidney disease secondary to anticoagulant therapy. Large numbers of tubular RBCs and/or tubular RBC casts and ATN, witho...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...