Wuhan No.1 Hospital

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

A semi-supervised deep learning framework (TBMNet) for automatic tumor budding quantification: real-world validation and clinical utility in stage II colorectal cancer

Abstract Background Tumor budding (TB) is a clinically important prognostic marker in colorectal cancer (CRC), but its assessment remains subjective and its biological basis is incompletely understood. We developed an artificial intelligence (AI)-based TB evaluation framework and...

Reconstruction of traumatic proximal femoral bone defects with personalized 3D-printed porous Ti-6Al-4V prosthesis: a case report and literature review

Abstract Background Reconstruction of critical-sized proximal femoral defects caused by high-energy trauma remains a formidable orthopedic challenge due to compromised mechanical stability, anatomical complexity, and limited biological integration capacity. Traditional methods (a...

52‐week ivarmacitinib in moderate‐to‐severe atopic dermatitis: A phase 3 trial

BACKGROUND: Ivarmacitinib, an oral JAK1 inhibitor, improved efficacy outcomes versus placebo at Week 16 in a phase 3 trial in patients with moderate-to-severe atopic dermatitis (AD). OBJECTIVES: To describe efficacy and safety outcomes through Week 52. METHODS: In this multicentr...

Early-life exposure to polypropylene microplastics and DEHP induces ASD-relevant neurodevelopmental alterations involving mTOR-regulated autophagy impairment

The health risks of polypropylene plastic, a major food-grade polymer, are often underestimated. Current evidence indicates that infants and young children may ingest millions of polypropylene microplastic particles (PP-MPs) daily, accompanied by co-exposure to di(2-ethylhexyl) p...

Associations of outdoor artificial light at night with type 2 diabetes and metabolic syndrome among Chinese adults

This study investigated the associations between outdoor artificial light at night (ALAN) and type 2 diabetes (T2DM) and metabolic syndrome (MetS) and aimed to characterize the dose-response relationships and potential exposure thresholds. This cross-sectional study included 57,8...

Surgical strategies for external auditory canal cholesteatoma based on the He staging system: a retrospective study

PURPOSE: To investigate individualized surgical treatment strategies and clinical management experience for external auditory canal cholesteatoma (EACC) based on the He staging system. METHODS: Clinical data from 59 patients (61 ears) with EACC who underwent surgical treatment at...