Wuhan Institute of Virology

Epitope and immunological basis for superior immunogenicity of henipavirus glycoprotein HeV.G over NiV.G in mRNA vaccines

Nipah (NiV) and Hendra (HeV) viruses are highly lethal zoonotic Henipaviruses with pandemic potential, for which no licensed vaccines exist. The surface glycoprotein (G) is the primary target of neutralizing antibodies, yet a systematic comparison of the immunogenicity of NiV.G a...

Global spread and evolutionary trajectories of HIV-1 CRF01_AE: Insights from phylogenetic analysis

HIV-1 circulating recombinant form (CRF) 01_AE has driven major HIV epidemics across Southeast and East Asia for decades, yet the mechanisms underlying its long-term regional spread remain poorly resolved. Using near-complete genome sequences and Bayesian phylogeographic reconstr...

Herpes simplex virus type 2 induces S-phase entry and arrest to regulate the cell cycle for efficient replication

Viruses often hijack core host cell processes to optimize their replication. In the current study, we conducted comparative proteomics analyses of epithelial cells infected by the prevalent human pathogen herpes simplex virus type 2 (HSV-2), followed by experimental validation. T...

HCMV US30 induces TMED10-DRP1-mediated mitochondrial fission and apoptosis to promote viral multiplication

Human cytomegalovirus (HCMV) hijacks host components to modulate cell death for its optimized replication and dissemination. We identified HCMV US30 as a viral factor that induces caspase-dependent apoptosis. US30 induces both DRP1-dependent mitochondrial fission and subsequent a...

Establishing Management Framework for Biosafety Risk Assessments of Synthetic Biology

Synthetic biology, an evolving interdisciplinary field encompassing revolutionary technologies, requires a comprehensive consideration of bioethics, and biosafety risks to drive scientific and technological advancements. To address these concerns, it is crucial to pay attention t...

Internal poly(A) replacement strategy within 3′ UTR for live-attenuated tick-borne encephalitis virus

Tick-borne encephalitis virus (TBEV), a prominent orthoflavivirus transmitted by ticks, poses a risk of potentially fatal encephalitis in humans. Currently, the only available inactivated vaccines have limited usage, underscoring the need for developing novel vaccine strategies....

Mechanism and plasticity of primitive pyroptosis

Pyroptosis is a proinflammatory form of regulated cell death across the tree of life. The gasdermin (GSDM) protein family functions as an evolutionarily conserved executioner of pyroptotic cell death by forming membrane pores. As the canonical activation mechanism, proteolytic cl...