Wuhan General Hospital of Guangzhou

Self-regulated immune-neurovascular bone repair scaffold via functional surface features

Given specific microenvironment of bone repair, the novel implant endowed with self-regulated bone healing procedure was the representative trend of bio-functional decoration. Inspired by the microstructure and chemical composition of natural bone, bioactive calcium titanate coat...

A bladder microenvironment-adaptive ceria nanozyme hydrogel enables urea-responsive intravesical chemo-immunotherapy

Bladder cancer intravesical therapy remains limited by rapid urinary washout, insufficient penetration across the bladder mucosal barrier, and an immunosuppressive tumor microenvironment. Here, we developed a bladder microenvironment-adaptive chemo-immunotherapy system, Gel/UCeNZ...

Anterior intervertebral osteotomy and fusion (AIOF): an IPUP-guided standardized extension of anterior cervical discectomy and fusion for multilevel cervical spondylotic myelopathy

Abstract Purpose To evaluate the clinical and radiographic outcomes of anterior intervertebral osteotomy and fusion (AIOF), guided by the inflection point of the uncinate process (IPUP), for the treatment of multilevel cervical spondylotic myelopathy (MCSM), and to compare these...

Mitral leaflet aneurysm and perforation: healed endocarditis mimicking degenerative valve disease

A 27-year-old male presented with six months of chest tightness, nocturnal diaphoresis, and progressive palpitations. He had no cardiac or rheumatic history; his only prior surgery was a remote hae...