Wuhan Children's Hospital

RAFA: RNA all-atom structure reconstruction from sparse anchor coordinates

SUMMARY: We present RAFA, a C ++ command-line tool for RNA all-atom structure reconstruction from sparse or partial coordinates. RAFA targets settings in which coarse-grained modelling, low-resolution fitting, or partial experimental interpretation provides RNA anchor atoms but n...

The mediating effects of depressive symptoms on the association between hobby engagement and functional disability: evidence from three cohort studies

Functional disability is a critical public health challenge in aging populations. While lifestyle factors have been extensively studied, the protective role of hobby engagement against functional decline remains underexplored. Thus, this study aimed to examine the association bet...

Applications of artificial intelligence in the analysis of alveolar clefts: a scoping review

Background Alveolar clefts are a prevalent clinical manifestation of cleft lip and palate (CLP), and are typically managed with secondary alveolar bone grafting (SABG) during mixed dentition. Nonetheless, considerable variability in the morphology and volume of the defect influen...

Dietary Fatty Acids, Cardiovascular Disease, and Life Expectancy Among Adults With Adverse Mental Health‐Related Characteristics: A Cohort‐Based Target Trial Emulation Study

ABSTRACT Adverse mental health‐related characteristics contribute to decreased life expectancy, largely driven by an elevated risk of cardiovascular disease (CVD). Dietary fatty acids influence disease occurrence and progression, yet the associations of polyunsaturated fatty acid...