Woodruff Health Sciences Center

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as...

Targeted Gastrointestinal Delivery of mRNA Lipid Nanoparticles Enables Systemic Vaccination and Glucagon-like Peptide-1 Metabolic Therapy

Abstract Lipid nanoparticles (LNPs) administered parenterally often show poor localization to multiple tissue types, including the pancreas and gastrointestinal (GI) tract. Furthermore, patients typically prefer orally administered drugs to those that are given parenterally. We t...

A Sequence-to-Scaffold Platform Enables Programmable Carrier-Supported Biocatalysis for Nucleoside Analog Synthesis

Abstract Industrial biocatalysis increasingly requires strategies that convert enzyme discovery into robust catalyst systems for process implementation. Here, we report Spatially Programmable Assembly of Computationally Mined Enzymes (SPACE), a sequence-to-scaffold workflow coupl...

Multicenter dataset describing emotional intelligence and counseling self-efficacy among clinical pastoral education students in healthcare settings

Emotional intelligence (EI) and counseling self-efficacy (CSE) are widely regarded as core professional competencies for healthcare chaplains. However, evidence on whether Clinical Pastoral Education (CPE) effectively develops these capacities remains limited. The parent study ge...

An Fc receptor and IgA functional signature identifies TB disease in children living with HIV

Abstract Background Tuberculosis (TB) is a leading cause of morbidity and mortality among children living with HIV (CLHIV). TB disease is difficult to detect with current clinical microbiological, immunological, and radiographic tools. Serological assays that determine levels of...

Impact of the Food4Moms produce prescription program on readiness for healthy eating, fruit and vegetable intake, and food security

Abstract Produce prescription programs (PRx) targeting different populations and conditions have been found to be effective. However, few have focused on pregnant women. The objectives of this study were to assess the impact of the Food4Moms (F4M) PRx on 1) healthy eating stages...

Fabry Disease: An Updated Perspective and Review of Treatment and Therapies

Fabry disease (FD) is a progressive, multisystemic, X-linked lysosomal storage disorder that when untreated leads to decreased quality of life, chronic pain, and end organ disease; however, advances in therapy have significantly altered its original natural history. This paper br...

Galactose-FunctionalRAFT Agent for Biorelevant PolymericMaterials

Abstract In this work, we report a novel chain transfer agent (CTA) derived from d-galactose and evaluate its potential as a reversible addition–fragmentation chain-transfer (RAFT) agent. Using this galactose-based CTA, Gal-RAFT, both hydrophilic and hydrophobic monomers were suc...

Amphiphilic Lipid–PolymerTriblock Architecturesas Nanocarriers for Therapeutic Delivery

Abstract This study investigates the formation and characterization of nanocarriers derived from the self-assembly of amphiphilic lipid-polymer hybrids (LPHs) engineered with a symmetric ABA block copolymer architecture. In this design, the terminal A-blocks comprise branched hyd...