Women's Hospital, School of Medicine, Zhejiang University

Extract from Eucommia ulmoides Oliv. Leaves alleviates APAP-induced acute liver injury via reshaping gut microbiota and attenuating microbial bile acids metabolism disorder

Abstract Background Increasing studies suggest that supplementing flavonoids from Eucommia ulmoides Oliv. Leaves (EUL) exerts liver protective effects via reshaping gut microbiota and regulating bile acids (BAs) metabolism. However, the relationship between EUL, gut microbiota an...

Vulvovaginal Myxoid Epithelioid Smooth Muscle Tumor With NCOA2 Rearrangement: Case Report and Literature Review

Vulvovaginal myxoid epithelioid smooth muscle tumor with NCOA2 rearrangement is an emerging, rare mesenchymal neoplasm of the female genital tract. We reported a 56-yr-old Chinese woman with a slow-growing, tender mass in the right labium majus. The tumor was composed of epitheli...

TEFM-mediated regulation of mitochondrial function enhances CAR-T cell activity in ovarian cancer peritoneal metastasis

Chimeric antigen receptor (CAR)-T cell therapy in solid tumours is frequently limited by progressive functional impairment and inadequate metabolic fitness within the tumour microenvironment. Mitochondrial transcription elongation factor (TEFM) is an essential regulator of mitoch...

Subtype-specific distribution of genetic disorders in congenital heart disease: a registry based study from China

Abstract Background Congenital heart disease (CHD) is the leading cause of birth defects. This study aimed to characterize the spectrum of genetic disorders associated with CHD. Methods CHD cases obtained from a provincial birth defect surveillance system in China between 2022 an...

Neddylation E2 enzyme UBE2M inhibits inflammatory lung tumor microenvironment by blocking the cGAS-STING signal upon KrasG12D activation.

activation in the lung.

Nanozyme‐Assisted Engineered Oncolytic Adenovirus for Improving Intratumoral Immune Deficiency and Enhancing Cancer Immunotherapy

ABSTRACT Oncolytic adenovirus (OA) exhibit tumor‐selective tropism, inducing direct oncolysis while simultaneously potentiating host immune responses against malignancies. However, the poor delivery efficiency of the virus targeting tumors and its limited immune activation capaci...

Association of systemic immune-inflammation index and neutrophil-to-lymphocyte ratio with all-cause mortality in patients with ovarian malignancies: a large retrospective cohort study

This study aims to evaluate the correlation between the Systemic Immune-Inflammation Index (SII) and the Neutrophil-to-Lymphocyte Ratio (NLR) with all-cause mortality in patients with ovarian malignant tumors. This single-center retrospective cohort study included 948 patients wi...

Transposable elements as evolutionary catalysts of ant macrodiversity

Transposable elements (TEs) are key contributors to genome evolution, yet their macroevolutionary roles in adaptive radiations remain poorly understood, as high-quality genomic resources at sufficient phylogenetic breadth and appropriate comparative methods have been lacking. Her...

MRI insights into endometrial stromal tumors

Abstract Preoperative misdiagnosis and the adoption of incorrect surgical approaches occur frequently in patients with endometrial stromal tumors (ESTs) because of their rarity, nonspecific clinical manifestations, and imaging features that highly overlap with those of other beni...

Changes in seminal plasma metabolites and the vital role of tyrosol in men with asthenozoospermia

Male factor infertility accounts for approximately 50% of all infertility cases. Metabolomics has recently been applied to the assessment of sperm quality and male fertility. However, studies on the biological functions and clinical effects of sperm metabolites in relation to ast...

Learning chemical-induced gene expression perturbations with WAVE

Chemical-induced transcriptional profiles facilitate systematic characterization of compound-driven perturbations, offering critical insights into mechanisms of action, especially for compounds with poorly defined molecular targets. However, experimentally profiling gene expressi...

Prenatal exploratory model for gestational trophoblastic neoplasia after hydatidiform mole with a coexistent normal fetus: a retrospective cohort study

Hydatidiform mole with a coexistent normal fetus (HMCF) has a relatively high risk of developing gestational trophoblastic neoplasia (GTN), but no prenatal model is currently available to estimate GTN risk after HMCF. For these reasons, we developed a prenatal exploratory model f...

Ultrasound-mediated mechanical force perturbing plasma membrane properties for paclitaxel-resistant epithelial ovarian cancer therapy

Abstract Paclitaxel (PTX) resistance in epithelial ovarian cancer (EOC) is a significant clinical challenge, often resulting in cross-resistance to other chemotherapeutic agents and contributing to a low five-year survival rate. In recent years, the physical characteristics of tu...

Localized immunohistochemical marker differences between cesarean scar niche and adjacent endometrium: a retrospective paired study

Cesarean scar niche (CSN) is associated with abnormal uterine bleeding after cesarean delivery, but tissue-level differences at the scar-endometrial interface remain poorly defined. We compared CSN tissue with adjacent endometrium from the same uterus, treating the latter as an i...

FOXD3 Is Functionally Linked to NF-κB Signaling in KRAS G12C-Mutant NSCLC Cells

KRAS G12C mutation is a clinically relevant driver in non-small cell lung cancer (NSCLC), yet the signaling networks that modulate malignant behavior in this context remain incompletely defined. In this study, we examined the functional role of FOXD3 and its relationship with NF-...

Genomic predisposition is associated with the direction of sex chromosome evolution

Sex chromosome evolution is among the most dynamic genomic innovations in vertebrates, yet why some lineages evolve XY while others evolve ZW remains unclear. Using chromosome-level genomes from 19 geckos, we found that gecko sex chromosomes originated independently from 16 ances...

lncRNAs contribute to caste differentiation as a regulatory layer in ants

Abstract Caste differentiation in ants represents one of the major evolutionary transitions and provides a unique model for studying developmental mechanisms underlying division of labor. Genetically identical individuals follow divergent epigenetically-regulated developmental tr...

Latent gene network expression underlies partial re-evolution of a polyphenic trait in the worker caste of ants

Polyphenisms–where alternative phenotypes develop from a single genome in response to environmental cues–are not only widespread in nature, but also occur at multiple levels of biological organization, from cells to individuals to societies. Polyphenism is thought to promote phen...

Acupoint hot compress for labor-pain management: a randomized, parallel-group, controlled trial

Background Non-pharmacological pain management approaches, including acupoint hot compress, may provide valuable support for women dealing with pain during the latent stage of labor, but the evidence supporting this effect is limited. We investigated whether acupoint hot compress...

Predicting Y chromosome microdeletions in male infertility patients using machine learning models: a retrospective clinical study

Y chromosome microdeletions (YCMs) are the second most prevalent genetic determinant of male infertility, but validated predictive models are limited. We retrospectively enrolled 4096 male infertility patients (October 2013–October 2023) for model development and randomly divided...