Women's Health Research Institute

HIV transmission behaviors, detectable HIV-RNA and curable STI prevalence among Ugandan men with HIV with reproductive goals, with and without infertility experiences

Many men with HIV (MWH) want children. MWH with unmet reproductive goals may prioritize conception over preventing HIV/STI transmission. Therefore, we evaluated whether MWH with unmet versus met reproductive goals were more likely to have detectable HIV-RNA or STIs, and explored...

Method for modeling oviduct function and impact on embryonic development

Direct experimental analysis of the mammalian oviduct is constrained by limited tissue access and the short lifespan of ex vivo preparations. Extracellular matrix-embedded three-dimensional epithelial organoids provide longer-term in vitro models. However, their inward-facing api...

Effects of neurokinin receptor antagonists on sleep disturbance in menopausal women: a systematic review and meta-analysis of randomized controlled trials

Importance: Sleep disturbance is a common and burdensome symptom among perimenopausal and postmenopausal women with moderate to severe vasomotor symptoms (VMS). Although neurokinin (NK) receptor antagonists have demonstrated efficacy for reducing VMS, their effects on sleep distu...

Characterization of mitochondria in trophoblast cells derived from control and early-onset preeclamptic pregnancies via induced pluripotent stem cells

Abstract Early embryonic development occurs in a low oxygen environment, and mitochondrial morphology and function are distinct in embryonic cells and pluripotent stem cells (PSC), which rely less on oxidative phosphorylation than differentiated cells. Oxidative phosphorylation i...