Women's and Children's Health Network

hpci improves reproducibility of computational biology research by integrating Continuous Integration with High Performance Computing clusters

Abstract Motivation The reproducibility crisis in bioinformatics and computational biology can be mitigated by using Continuous Integration (CI), a proven software engineering practice, to automate the testing of analysis pipelines and models. However, the adoption of CI in bioin...

Quality of life and supportive care among informal caregivers of people with cancer during a critical illness in the ICU: A mixed methods systematic review

Objectives To synthesise the evidence on the experiences of HRQoL, psychological well-being, and supportive care needs among informal caregivers of patients with cancer in the ICU and the experiences of the MDT to deliver supportive care. Methods This mixed methods systematic rev...

Diet Quality and Weight Gain Among Women in the Aboriginal Family Birthing Program in South Australia

Background: This study assessed diet quality and the association between engagement with nutrition support bundles and weight gain among pregnant women having Aboriginal and Torres Strait Islander babies who participated in the Aboriginal Family and Baby Bundles implementation pr...

Experience, influences, and impacts on breathlessness among people receiving care in the intensive care unit: A qualitative study

Introduction Breathlessness is frequently experienced by patients in the intensive care unit (ICU) and associated with anxiety and delays in weaning from mechanical ventilation. Breathlessness in this clinical setting remains under-recognised in clinical guidelines, and little is...

Preparing for Future Group B Streptococcus Vaccines: Perspectives of Pregnant Women in Australia

Background: Vaccines for Group B Streptococcus (GBS) intended for pregnant women are currently in advanced stages of clinical trials. Conducting preparatory research now can help identify factors influencing GBS vaccine acceptance and potential challenges to future implementation...

Sickle cell disease and hematopoietic stem cell transplantation: donor expansion, gene-modified grafts and prenatal horizons

Purpose of review To review advances from the past 18 months in allogeneic hematopoietic stem cell transplantation (HSCT) and autologous gene-modified stem cell transplantation for sickle cell disease (SCD), and to relate these developments to stem cell biology, conditioning and...

Inclusive by design: an implementation framework for culturally responsive research advisory panels

Abstract Background Culturally and linguistically diverse (CALD) communities remain underrepresented in health research despite experiencing substantial health inequities. Community advisory panels are increasingly recommended to strengthen community engagement, cultural responsi...

A qualitative analysis to identify implementation strategies for a deprescribing clinical practice guideline using the CFIR-ERIC Matching Tool: perspectives from consumers and professional stakeholders

Abstract Introduction Deprescribing is the planned withdrawal or dose reduction of medicines when harms outweigh benefits or when they are no longer required. Following publication of the Clinical Practice Guideline for Deprescribing in Older People in September 2025, supporting...

A bone histological approach to distinguish periprosthetic joint infection from aseptic osteolysis in revision joint replacement

Aims Accurate differentiation between periprosthetic joint infection (PJI) and aseptic osteolysis (AO) remains a major clinical challenge in revision joint arthroplasty. We examined bone biopsies for alterations in bone matrix integrity and the osteocyte lacunocanalicular network...