Woman's Hospital

Development of an investigational epigenetic silencer therapy to transcriptionally inactivate viral DNA in chronic hepatitis B

Approved chronic hepatitis B therapies rarely result in functional cure, as they fail to permanently silence all transcriptionally active hepatitis B virus (HBV) DNA. CRMA-1001 employs an optimized epigenetic silencer that represses viral transcription through targeted deposition...

Exploring the mediating role of working alliance in a peer support intervention for late-life depression

Objective: Peer support is an evidence-based intervention for depression, yet the mechanisms underlying its effectiveness remain understudied, particularly in randomized clinical trials. This study examined the mediating role of working alliance components (task, bond, and goal)...