Wolfson Foundation

Cellular Senescence and Immune Dysregulation in Acute-on-Chronic Liver Failure: A Case Report Integrating Single-Cell and Spatial Transcriptomic Profiling

Background: Acute-on-chronic liver failure (ACLF) is a clinical syndrome characterized by acute decompensation of cirrhosis, systemic inflammation, and high short-term mortality (1). The underlying mechanisms involve a complex interplay between cellular senescence, immune dysregu...

Cellular Senescence and Immune Dysregulation in Acute-on-Chronic Liver Failure: A Case Report Integrating Single-Cell and Spatial Transcriptomic Profiling

Background: Acute-on-chronic liver failure (ACLF) is a clinical syndrome characterized by acute decompensation of cirrhosis, systemic inflammation, and high short-term mortality (1). The underlying mechanisms involve a complex interplay between cellular senescence, immune dysregu...