Winship Cancer Institute

Denosumab in multiple myeloma patients with severe renal impairment: a multicenter phase 2 study

Lytic bone lesions are a defining characteristic of multiple myeloma (MM) and one of its most significant clinical consequences. Bone-modifying agents, including the bisphosphonates zoledronic acid and pamidronate, as well as the receptor activator of nuclear factor-κB ligand (RA...

Knockdown of the long isoform of the prolactin receptor selectively targets pathogenic immune cells in systemic lupus erythematosus and averts glomerular pathology

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by chronic inflammation in multiple organ systems. Although elevated circulating levels of the hormone/cytokine prolactin (PRL) have long been associated with increased SLE activity, the extent to which dif...

Cost-Effectiveness of Remote Symptom Monitoring During Adjuvant Endocrine Therapy in Breast Cancer

Importance Adjuvant endocrine therapy (AET) reduces recurrence and mortality for women with early-stage hormone receptor–positive breast cancer, yet long-term adherence is suboptimal, largely due to treatment-related symptoms. Remote patient monitoring (RPM) is a potential strate...

PolarTIL programming reveals an essential role for TGF-β1 in antitumor memory in human cutaneous malignancies

Abstract Tumor-infiltrating lymphocyte (TIL) therapy can induce tumor regression in solid malignancies, yet durable responses remain limited, highlighting the need for more effective cell products. Here, we generated a novel TIL product, PolarTIL, by polarizing murine and human T...

Thy1-Neuron p38α knockdown protects against neurological consequences following repetitive mild traumatic brain injury

Mild traumatic brain injuries (mTBI) can substantially impact quality of life, and repetitive mTBIs (rmTBIs) can amplify injury effects compared to a single injury. However, effective clinical treatments remain elusive, largely due to an incomplete understanding of the underlying...

Reprogramming the tumor immune landscape through SPP1 targeting

Abstract Beyond its canonical roles in bone mineralization and extracellular matrix remodeling, secreted phosphoprotein 1 (SPP1) has emerged as a central regulator of the tumor microenvironment (TME), orchestrating immunosuppressive programs that drive immune evasion and tumor pr...

Physician- and Practice-Level Variation in Clinical Trial Participation Among Patients With Advanced Cancer

Importance Clinical trial enrollment is essential to advancing cancer care, yet participation among patients with advanced cancer remains low. While patient-level barriers are frequently cited, the role of health care delivery factors—specifically physician- and practice-level va...

Redefining leptomeningeal metastasis in non–small cell lung cancer: From terminal complication to molecularly managed disease

Leptomeningeal disease (LMD) is one of the most devastating complications of advanced non-small cell lung cancer (NSCLC), historically associated with profound neurologic morbidity and poor survival. Advances in cerebrospinal fluid (CSF)-based diagnostics, improved molecular char...

A phase II pilot trial of an indoleamine 2,3-dioxygenase-1 (IDO1) inhibitor (INCB024360) plus a multipeptide melanoma vaccine (MELITAC 12.1) in patients with advanced melanoma, with sequential evaluation of the tumor microenvironment

Indoleamine 2,3-dioxygenase-1 (IDO1) can mediate immune dysfunction by reducing tryptophan (Trp) and increasing kynurenine (Kyn). The CITN-04 clinical trial (NCT01961115) tested the safety and clinical activity of combination therapy with IDO1 inhibitor epacadostat (INCB024360) p...

Proteolytic Activation of T Cell Engagers And Bispecific Proteins Using Modular Coiled-Coil Peptides

Abstract Bispecific T cell engagers (BiTEs) are engineered immunotherapeutic molecules designed to direct the body’s immune system against malignant cells by physically connecting T cells to target cells, triggering cytotoxic responses. BiTEs have typically engaged T cells via αC...

Management of Soft Tissue and Visceral Leiomyosarcomas

Importance Leiomyosarcoma is a rare and heterogeneous malignant mesenchymal neoplasm associated with substantial morbidity and mortality. Given recent advances in biologic understanding and the complexity of leiomyosarcoma, a consensus-driven approach is needed to harmonize manag...

Genomic and Transcriptomic Landscapes of MEN1-Wild-Type Low-Grade Metastatic Pancreatic NETs Uncover Key Oncogenic Drivers and Targetable Pathways

Sporadic pancreatic neuroendocrine tumors (pNETs) with wild type MEN1 represent a major yet largely ignored subset whose biology and metastatic potential remain poorly understood. Because metastasis can occur despite low histologic grade and modest mutational burden, we hypothesi...