Institution
WinnMed
Recent research
- Health & MedicineOpen access
Highlights of the 2025 American Joint Replacement Registry Annual Report
The 2025 American Joint Replacement Registry Annual Report includes 4.6 million hip and knee arthroplasty procedures, with 4,434,668 validated cases, representing a 20% increase from the prior report. Registry participation continues to expand, with contributions from over 5000 s...
- Health & MedicineOpen access
The effect of induced hypertension (iHTN) on functional outcomes in noncardioembolic acute ischemic stroke (AIS) with early neurological deterioration remains unclear. We performed a systematic review and meta-analysis evaluating the safety and efficacy of iHTN vs medical managem...
- Health & MedicineOpen access
Abstract Introduction Fetal growth restriction (FGR) is associated with an increased risk of neonatal morbidity and mortality. Current diagnostic criteria for FGR do not discriminate between constitutionally small and pathologically restricted fetuses. Following FGR diagnosis, um...
- Health & MedicineOpen access
Moral emotion processing in euthymic bipolar disorder: insights from network analysis
Abstract Background Bipolar disorder (BD) is associated with facial emotion recognition (FER) deficits. Among these, impairments in recognizing moral emotions may be especially relevant to social dysfunction, but their relationship with brain structure remains poorly defined. Met...
- Health & MedicineOpen access
Senescent peripheral fibroblasts initiate chemotherapy-induced peripheral neuropathy
All raw data files to support manuscript.
- Health & MedicineOpen access
Abstract Provide expert-informed guidance on the integration of aflibercept 8 mg into routine clinical care for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO), based on clinical trial and real-world evidence. Sixteen retina spe...
- Health & MedicineOpen access
Sequential FIB-4–based testing limits detection of fibrotic MASLD despite optimized ELF thresholds
Background: Societal guidance recommends sequential noninvasive testing for metabolic dysfunction–associated steatotic liver disease (MASLD), using Fibrosis-4 (FIB-4) ≥1.3 as a gatekeeper before second-line assessment with the Enhanced Liver Fibrosis (ELF) score (<7.7 as a rul...
- BiologyOpen access
Background Prognostic staging systems in transthyretin amyloid (ATTR) cardiomyopathy were developed before the introduction of disease‐modifying treatment. We therefore evaluated contemporary risk stratification according to different staging systems in patients with ATTR cardiom...
- BiologyOpen access
OntoCodex: a multi-agent biomedical ontology enrichment framework
Ontology enrichment is a critical but labor-intensive step in semantic knowledge representation. To address this challenge, we propose OntoCodex, a multi-agent framework that integrates large language models (LLMs), ontologies, curated knowledge sources, and standard vocabularies...
- Health & MedicineOpen access
Importance: Chronic liver disease requires sustained engagement with the health system, which co-occurring social and functional risks may disrupt. Whether these risks form reproducible patterns with different mortality associations is uncertain. Objective: To identify social and...
- BiologyOpen access
TRAIL is a TNF family ligand that trimerizes TRAIL-R1 (DR4) or TRAIL-R2 (DR5) to induce apoptosis, necroptosis, and/or NF-κB activation in receptor-bearing cells. We previously identified TRAILshort as a splice variant of TRAIL that lacks cysteine 230, cannot trimerize, and acts...
- Health & MedicineOpen access
The total number of total hip arthroplasties performed each year is expected to increase significantly over the coming decades. As a result, an increasing number of young patients are undergoing total hip arthroplasty while similarly, a growing subset of active elderly patients d...