Wilmington University

Neurodegeneration and inflammation in a novel spinocerebellar ataxia 13 preclinical model

Abstract Neuroinflammation is a critical pathological feature underlying neurodegenerative diseases. Spinocerebellar ataxia 13 (SCA13) is a heterogeneous ataxia with several allelic variations of differing phenotypes. All are neurodegenerative and currently without effective trea...

Lithium Ascorbate May Support Weight Loss Within the Depression-Obesity Feedback Loop

Depression and obesity frequently coexist and may reinforce one another through biological, behavioral, and psychosocial mechanisms, complicating both mood management and weight reduction. This paper reviews the depression–obesity feedback loop, current approaches to major depres...

AI failures in the eyes of the downstream developer: a first look at concerns, practices, and challenges

Abstract With the advancement of AI models, more software systems are adopting AI as a component to facilitate automation. Pre-trained models (PTMs) have become a cornerstone of AI-based software, allowing for rapid integration and development with lower training cost. However, t...