Westmead Hospital

Beyond the protocol: navigating ethics and governance in the multicentre implementation trials – the QASC Australasia and T3 Trials

OBJECTIVE: To describe and compare ethics and governance approval timelines for the Quality in Acute Stroke Care (QASC) Australasia Trial (2021-present) and Triage, Treatment, and Transfer of Patients with Stroke in Emergency Departments (T3) Trial (2012-2014), benchmarking again...

A multi-centre study of belatacept and sirolimus for islet transplantation

Abstract Aims/hypothesis Islet transplantation is an appropriate treatment for selected individuals with type 1 diabetes mellitus and hypoglycaemia unawareness. The gold standard of maintenance immunosuppression to prevent allograft rejection is calcineurin inhibitor-based therap...

Fibrinogen Early In Severe Trauma studY II (FEISTY II): study protocol for a randomised clinical trial of fibrinogen concentrate vs cryoprecipitate in traumatic haemorrhage in Australia and New Zealand

Haemorrhage is a leading cause of preventable death amongst severe trauma patients and is often complicated by hypofibrinogenaemia. Fibrinogen replacement can be achieved using fibrinogen concentrate (FC) or Cryoprecipitate (Cryo), but comparative evidence in traumatic haemorrhag...

Intrapartum Febrile Morbidity and Maternal Birth Trauma After Vaginal Delivery: A Parity-Stratified Retrospective Cohort Study

Objective: We aimed to evaluate the association between intrapartum febrile morbidity and maternal birth trauma among women undergoing vaginal delivery, with stratification by parity. Methods: This retrospective cohort study included women with singleton, cephalic, vaginal delive...

How Feasible is the Use of Saliva for Antiviral Therapeutic Drug Monitoring? A Systematic Review and Analysis

Immunosuppressed patients are susceptible to serious viral infections, often necessitating antiviral prophylaxis and/or treatment. Therapeutic drug monitoring (TDM) has been proposed to optimise drug exposure and clinical outcomes and is typically performed on full blood/plasma s...

Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapy

Optimal dosing of vancomycin in critically ill patients receiving renal replacement therapy (RRT) is uncertain due to high pharmacokinetic variability. We aimed to develop individualised vancomycin dosing recommendations that optimise efficacy while minimising toxicity. Prospecti...

Current Evidence on Best Practice Dental Survivorship Care for People With Head and Neck Cancer: An Overview of Systematic Reviews and Emerging Evidence

INTRODUCTION: Head and neck cancer (HNC) survival is improving, increasing the need to address long-term survivorship issues. Dental survivorship-care before, during, and after treatment-remains inconsistent across services. We conducted a review of systematic reviews and emergin...

Outcomes following dialysis and transplantation in amyloidosis: ANZDATA analysis

Abstract Background The kidneys are frequently affected by systemic amyloidosis. Despite this, contemporary survival outcomes for patients reaching kidney failure due to amyloidosis remain poorly defined relative to other causes of kidney failure. This study aims to characterise...