Westlake Health Center

Biocatalytic Redox Cascade Enabled Site-Selective Direct β-Alkylation of Cyclopentanones

Abstract Alkylation of carbonyl compounds is among the most widely practiced transformations in organic synthesis. While extensive methods exist for functionalization at the ipso and α-positions, direct β-alkylation remains a significant challenge, especially for cyclic ketones....

Gut Microbiota-Derived Indole-3-propionic Acid Attenuates Titanium Dioxide Nanoparticle-Induced Liver Injury by Targeting Kupffer Cells via the Gut–Liver Axis

Abstract Nanotitanium dioxide (nTiO2) is widely used as a food additive, leading to chronic dietary exposure and rising health concerns. Although adverse effects on the liver and gut microbiota have been individually investigated, whether gut microbiota mediates nTiO2-induced liv...

Enantioselective Convergent Synthesis of Heterohelicenes via Copper-Catalyzed Propargylic Annulation/Acid-Promoted Aromatization

Abstract Heterohelicenes combine helical chirality with tunable electronic properties, making them attractive for applications in chiral materials and optoelectronics. However, their enantioselective synthesis, particularly for five-membered heterohelicenes, remains a long-standi...