West China Second University Hospital of Sichuan University

Clinical performance of obstetric antiphospholipid syndrome classification criteria: an ambispective cohort study

Abstract Objectives To evaluate the clinical performance of the 2006 Sydney and 2023 ACR/EULAR classification criteria for obstetric antiphospholipid syndrome (OAPS), compare subsequent pregnancy outcomes across classifications and develop a supplementary classification method to...

Programmable Temperature‐Capped Dressing for Enhanced Wound Healing, Bacterial Clearance, and Inflammatory Modulation

ABSTRACT Reconciling efficient bacterial eradication with tissue safety remains a challenge in photothermal therapy (PTT) because of open‐loop thermal actuation. Herein, we propose a detachable bilayer hydrogel dressing comprising a poly(N‐isopropylacrylamide) (PNIPAM)‐based prot...

VGLL4 Suppresses Malignant Phenotypes of Clear Cell Renal Cell Carcinoma Cells Through Modulation of Hippo/YAP and Wnt/β-Catenin Signaling Pathways

Background/Objectives: Clear cell renal cell carcinoma (ccRCC), the most common and aggressive subtype of kidney cancer, continues to face challenges in early diagnosis and treatment, driving the need for reliable biomarkers and therapeutic targets. Vestigial-like family member 4...

Evolution and paradigms in ion channel and cardiac remodeling

Objective: This study aims to conduct a bibliometric analysis of the literature on the role of ion channels in cardiac remodeling. Methods: Articles on ion channels and cardiac remodeling from 1979 to 2024 were retrieved from the Web of Science Core Collection (WoSCC). Bibliometr...

Knowledge and attitudes of nurses and nursing students about Alzheimer’s disease: a systematic review and meta-analysis

With the global aging population, the burden of Alzheimer’s disease (AD) is increasing, underscoring the critical need for competent AD care. While previous studies have explored nursing personnel’s knowledge of and attitudes toward AD, a comprehensive synthesis across diverse cu...

Integrative identification and preliminary validation of senescence-associated secretory phenotype-related candidate biomarkers in type 2 diabetes

Senescence-associated secretory phenotype (SASP)-related inflammatory programs have been implicated in type 2 diabetes mellitus (T2DM), yet blood-based candidates have not been systematically screened and validated across independent cohorts. We adopted standardized senescence si...

Population Pharmacokinetics of Topical Timolol Maleate Gel in Healthy Volunteers and Infants With Superficial Infantile Hemangioma

Although timolol ophthalmic solutions or hospital-compounded formulations have been used off-label for the treatment of superficial infantile hemangioma (IH), no topical timolol formulation has been developed specifically for this indication. This study was the first to develop a...

Postoperative Sleep Disturbance and Functional Recovery Following Hip Fracture Surgery: A 13‐Month Prospective Longitudinal Cohort Study

ABSTRACT Background Sleep disturbances are common after hip fracture surgery and may adversely affect postoperative recovery. However, the longitudinal course of sleep quality and its relationship with functional recovery remain poorly understood. This study aimed to characterize...

Multimodal Exploratory Analysis of Persistent Diabetic Macular Edema: Integrating Aqueous Humour Metabolomics, Clinical and OCT Features

ABSTRACT Purpose This exploratory study integrates aqueous humour metabolomic data with clinical and imaging features to examine candidate biomarkers and characterize multimodal patterns associated with persistent diabetic macular edema (pDME). Methods In this prospective cohort...

Association between COVID-19 and exacerbation of allergic skin diseases

Coronavirus disease 2019 (COVID-19) has been linked to systemic immune dysregulation and various cutaneous manifestations, but its association with chronic allergic skin diseases, including atopic dermatitis (AD) and chronic urticaria (CU), remains unclear. This retrospective que...

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

ABSTRACT Sepsis‐induced pediatric acute lung injury (ALI) and pediatric acute respiratory distress syndrome (PARDS) are life‐threatening conditions with high mortality rates and no current cure. Most ALI/ARDS studies focus on adults, albeit the pediatric population has unique cha...

Dynamic association between gut microbiota succession and host metabolism: differential effects of antibiotic intervention duration on glucose and lipid metabolism in high-fat diet-induced obese mice

Abstract Background The gut microbiota plays a critical role in the onset and progression of obesity. Previous studies have indicated that antibiotic administration may influence host physiology and pathology by modulating the gut microbiota. However, whether different durations...

Extraventricular neurocytomas stratified by tumor location and histological subtype: clinical features, radiology, pathology, and prognosis

Abstract Objective To compare the differences in clinical manifestations, imaging features, histological characteristics, and prognostic outcomes of extraventricular neurocytomas (EVNs) based on tumor location (parenchymal vs. sellar) and histological subtype (typical vs. atypica...

Maternal gestational diabetes mellitus and mental disorders, neurodevelopmental disorders, and neurodevelopmental scale outcomes in offspring: a systematic review and meta-analysis

The association between maternal gestational diabetes mellitus (GDM) and neuropsychiatric outcomes in offspring has not been fully systematically synthesized. We aimed to evaluate the association between maternal GDM and neuropsychiatric outcomes in offspring, including mental di...

Family resilience and its influencing factors among families of children with malignant tumors during initial chemotherapy: a cross-sectional study

Abstract Background During the primary chemotherapy of pediatric malignant tumors, the physical and mental health of family members can be seriously affected. Family resilience has been shown to be a protective factor. Objectives To investigate family resilience in families with...

Impact of inoculation of inactivated COVID-19 vaccine on the outcomes of frozen-thawed embryo transfer

Abstract To assess the impact of inoculation of inactivated corona virus disease 2019 (COVID-19) vaccine on the outcome of frozen-thawed embryo transfer (FET). From January 2022 to November 2023, patients aged 20 ~ 45 years old undergoing FET at the Reproductive Medicine Center o...

Diagnosis and Management of Chronic Endometritis: Effects on Postoperative Pregnancy Outcomes in Endometriosis Patients with Proximal Tubal Obstruction Undergoing Hysteroscopic Tubal Catheterization and Laparoscopy

Background: This study aims to investigate the impact of chronic endometritis (CE) diagnosis and treatment on pregnancy outcomes during hysteroscopic fallopian tube catheterization combined with laparoscopy in infertility patients with pelvic endometriosis (EMS) and proximal tuba...

Site-specific programming characterizes dynamic post-translational acetylation of histone H2B lysine 108 in mouse embryonic stem cells

Dynamic histone modifications are critical for regulating stem cell fate. However, generalized strategies for site-specific programming of histone modifications profiling on unperturbed chromatin in embryonic stem cells (ESCs) remain challenging. In this study, we established a g...

The platelet-to-high-density lipoprotein cholesterol ratio as a potential biomarker linking tobacco exposure to accelerated reproductive aging in women

Female reproductive aging, commonly reflected by menopausal age and reproductive lifespan, is influenced by environmental exposures and metabolic health, and tobacco exposure has been associated with earlier menopause and shortened reproductive lifespan. Because this association...

Risk factors for surgical site infection after internal fixation for thoracolumbar fractures

The purpose of this study was to investigate the risk factors for surgical site infection (SSI) after internal fixation by posterior approach in patients with thoracolumbar fractures. According to whether SSI occurred after internal fixation, patients were divided into SSI group...