West China Second University Hospital of Sichuan University

Latent profile analysis of social alienation and its influencing factors in patients undergoing maintenance hemodialysis

Social alienation severely impairs the mental health and quality of life of patients undergoing maintenance hemodialysis (MHD). However, most studies conducted have been variable-centered, group-level analyses, which cannot capture inherent heterogeneity in social alienation, hin...

Association of pre-clinical depressive symptoms and its plasma metabolomic signature with Parkinson’s disease: a community-based longitudinal study

Abstract Accumulating evidence has suggested that depression is associated with an increased risk of Parkinson’s disease (PD), yet whether pre-clinical depressive symptoms in PD development and the potential mediating effects of metabolomic profiles remain unclear. We aimed to ex...

A gut microbiome‐lipid axis in early pregnancy is associated with metabolic dysregulation and diabetes risk

Abstract Gestational diabetes mellitus (GDM) reflects metabolic dysregulation that becomes clinically apparent during pregnancy and shares key pathophysiological features with broader forms of diabetes. Gut microbiome‐host metabolic interactions may contribute to this process, ye...

Factors associated with exclusive breastfeeding at 6 weeks postpartum in Southwest China: a cross-sectional study

Breastfeeding is known to be shaped by a complex interplay of socio-demographic, medical, and psychological factors. However, there is a lack of research on the determinants of breastfeeding at 6 weeks postpartum. This study aimed to examine factors associated with exclusive brea...

A real-time PCR-based noninvasive prenatal RHD screening assay optimized for population-specific RHD allelic spectra in China

Background Prenatal RhD screening enables risk stratification for RhD-associated hemolytic disease of the fetus and newborn (HDFN) and supports rational，evidence-based use of prophylactic anti-RhD immunoglobulin. However, noninvasive prenatal RhD screening remains challenging in...

Decoding how macronutrients influence depressive symptoms: Combined insights from regression, nonlinear modeling, and machine learning: a cross-sectional study using NHANES data

Dietary management is an essential component of comprehensive depression care;however, studies simultaneously evaluating multiple macronutrients and their associations with depressive symptoms are limited. Data from National Health and Nutrition Examination Survey 2005 to 2023 we...

Prevalence of disease related malnutrition assessed by NRS2002, STAMP, MNA-SF, one-step and two-step GLIM at admission and discharge: A systematic review and meta-analysis.

BACKGROUND AND OBJECTIVES: Disease-related malnutrition (DRM) mandates routine screening in many nations to ensure quality care as nutritional status often deteriorates during hospitalization. This study aimed to establish tool-specific prevalence benchmarks at admission and disc...