Wenzhou Institute, University of Chinese Academy of Sciences

Next-Generation Intelligent Adaptive Micro/Nanorobots for Precise Intervention of Central Nervous System Injuries: Advances, Clinical Hurdles, and Future Directions

Abstract Central nervous system (CNS) injuries, including traumatic brain injury, spinal cord injury, and stroke, are associated with high rates of disability and mortality. Challenges such as the obstruction of drug delivery by biological barriers, disrupted neuronal energy meta...

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

ABSTRACT Postmenopausal osteoporosis is caused by excessive osteoclast‐mediated bone resorption. This study identifies mitochondrial oxidative phosphorylation (OXPHOS) as a tractable metabolic target for antiresorptive therapy. A literature‐guided drug repurposing screen focused...

Enteric-gated nano–probiotic living nanozyme for gut-directed redox–mitochondrial protection in cisplatin-induced acute kidney injury

Oral nano-biohybrid therapeutics provide opportunities for gut–organ axis intervention, but gastrointestinal transit often compromises both probiotic viability and nanozyme activity. Here, we developed CeO 2 @LP@EL, an enteric-gated nano–probiotic living nanozyme constructed by d...

Role of desolvation on biomolecular liquid–liquid phase separation

Abstract Biomolecular condensates play essential roles in cellular organization and are implicated in diverse pathological processes. Their formation is driven by liquid-liquid phase separation (LLPS), a process that requires coordinated multistep desolvation of biomolecular chai...